Radiosensitising Nanoparticles as Novel Cancer Therapeutics - Pipe Dream or Realistic Prospect?

J. A. Coulter, W. B. Hyland, J. Nicol, F. J. Currell

Research output: Contribution to journalArticlepeer-review

Abstract

The field of high atomic number nanoparticle radiosensitising agents is reviewed. After a brief discussion of the new mode of physicochemical action implied by irradiation of high atomic number nanoparticles embedded in biological systems, a series of exemplars are discussed. Silver-, gadolinium- and gold-based nanoparticles are discussed in order of increasing atomic number with functionalisation strategies being outlined. In vitro and in vivo evidence for radio-enhancement and the mechanisms attributed to the increased biological effect are discussed.
Original languageEnglish
Pages (from-to)593-603
Number of pages10
JournalClinical Oncology
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Cancer
  • nanoparticles
  • nanotechnology
  • radiation dose enhancement

Research Beacons, Institutes and Platforms

  • Dalton Nuclear Institute

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