Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

Manikandan Kadirvel; Deborah Cardoso; Sally Freeman; Gavin Brown

doi:10.1007/s10967-018-5948-4

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

Manikandan Kadirvel, Deborah Cardoso, Sally Freeman, Gavin Brown

Research output: Contribution to journal › Article › peer-review

Abstract

N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

Original language	English
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	317
Issue number	2
Early online date	19 Jun 2018
DOIs	https://doi.org/10.1007/s10967-018-5948-4
Publication status	Published - Aug 2018

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title = "Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole",

abstract = "N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.",

author = "Manikandan Kadirvel and Deborah Cardoso and Sally Freeman and Gavin Brown",

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T1 - Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

AU - Kadirvel, Manikandan

AU - Cardoso, Deborah

AU - Freeman, Sally

AU - Brown, Gavin

PY - 2018/8

Y1 - 2018/8

N2 - N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

AB - N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

U2 - 10.1007/s10967-018-5948-4

DO - 10.1007/s10967-018-5948-4

M3 - Article

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VL - 317

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

Abstract

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