TY - JOUR
T1 - Raised mammographic density
T2 - Causative mechanisms and biological consequences
AU - Sherratt, Michael J.
AU - McConnell, James C.
AU - Streuli, Charles H.
PY - 2016/5/3
Y1 - 2016/5/3
N2 - High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties of high X-ray density soft tissues, and the causative mechanisms resulting in different mammographic densities, are not well described. Moreover, it is not known how high breast density leads to increased susceptibility for cancer, or the extent to which it causes the genomic changes that characterise the disease. An understanding of these principals may lead to new diagnostic tools and therapeutic interventions.
AB - High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties of high X-ray density soft tissues, and the causative mechanisms resulting in different mammographic densities, are not well described. Moreover, it is not known how high breast density leads to increased susceptibility for cancer, or the extent to which it causes the genomic changes that characterise the disease. An understanding of these principals may lead to new diagnostic tools and therapeutic interventions.
UR - http://www.scopus.com/inward/record.url?scp=85008675591&partnerID=8YFLogxK
U2 - 10.1186/S13058-016-0701-9
DO - 10.1186/S13058-016-0701-9
M3 - Article
AN - SCOPUS:85008675591
SN - 1465-5411
VL - 18
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 45
ER -
