Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- carbohydrate-carbohydrate interaction
- Lewis X
- peptide reporter