Random-coil:α-helix equilibria as a reporter for the Lewis X-Lewis X interaction

Timothy M. Altamore, Christian Fernández-García, Andrew H. Gordon, Tina Hübscher, Netnapa Promsawan, Maxim G. Ryadnov, Andrew J. Doig, Derek N. Woolfson, Timothy Gallagher

    Research output: Contribution to journalArticlepeer-review


    Probing weak interactions: A peptide random-coil:α-helix equilibrium has been used to identify a weak carbohydrate-carbohydrate interaction (CCI). Glucose and lactose destabilized the helical conformer while Lewis X trisaccharide led to increased helicity. Though small, the trend observed indicates that this peptide reporter can detect a single CCI in isolation. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)11167-11171
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Issue number47
    Publication statusPublished - 18 Nov 2011


    • carbohydrate-carbohydrate interaction
    • Lewis X
    • peptide reporter


    Dive into the research topics of 'Random-coil:α-helix equilibria as a reporter for the Lewis X-Lewis X interaction'. Together they form a unique fingerprint.

    Cite this