Random uptake of nanoparticles by cells and negative binomial distributions of pits

Vladimir Sholokhov; Dmitri V. Alexandrov; Eugenya V. Makoveeva; Margarita A. Nikishina; Vladimir Y. Shur; Ekaterina V. Shishkina; Marina P. Sutunkova; Ilzira A. Minigalieva; Yulia V. Ryabova; Larisa I. Privalova; Sergei Fedotov

doi:10.1140/epjs/s11734-024-01229-9

Random uptake of nanoparticles by cells and negative binomial distributions of pits

Vladimir Sholokhov, Dmitri V. Alexandrov, Eugenya V. Makoveeva, Margarita A. Nikishina, Vladimir Y. Shur, Ekaterina V. Shishkina, Marina P. Sutunkova, Ilzira A. Minigalieva, Yulia V. Ryabova, Larisa I. Privalova, Sergei Fedotov

Applied Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

This paper focuses on a key experimental observation concerning the random internalization of nanoparticles by cells: the occurrence of over-dispersion in nanoparticle uptake which can be characterized by a negative binomial distribution. We compare the well-known distribution with the empirical distribution of pits on the surface of an alveolar macrophage. We find that a negative binomial distribution provides the accurate curve-fit model for the observed pit distribution.

Original language	English
Number of pages	6
Journal	The European Physical Journal. Special Topics
DOIs	https://doi.org/10.1140/epjs/s11734-024-01229-9
Publication status	Published - 3 Jul 2024

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Sholokhov, V., Alexandrov, D. V., Makoveeva, E. V., Nikishina, M. A., Shur, V. Y., Shishkina, E. V., Sutunkova, M. P., Minigalieva, I. A., Ryabova, Y. V., Privalova, L. I., & Fedotov, S. (2024). Random uptake of nanoparticles by cells and negative binomial distributions of pits. The European Physical Journal. Special Topics. https://doi.org/10.1140/epjs/s11734-024-01229-9

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AU - Shur, Vladimir Y.

AU - Shishkina, Ekaterina V.

AU - Sutunkova, Marina P.

AU - Minigalieva, Ilzira A.

AU - Ryabova, Yulia V.

AU - Privalova, Larisa I.

AU - Fedotov, Sergei

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Random uptake of nanoparticles by cells and negative binomial distributions of pits

Abstract

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