Randomised controlled trial of early detection and cognitive therapy for preventing transition to psychosis in high-risk individuals. Study design and interim analysis of transition rate and psychological risk factors

A. P. Morrison, R. P. Bentall, P. French, L. Walford, A. Kilcommons, A. Knight, M. Kreutz, S. W. Lewis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: There is interest in the possibility of indicated prevention of psychosis. There is a strong case for using psychological approaches to prevent transition to psychosis in high-risk patients. Aims: To identify individuals at high risk of transition to psychosis, and psychological characteristics relevant to the development of psychosis in this group. Method: The design ora randomised controlled trial of cognitive therapy for the prevention of psychosis in people at high risk (meeting operational criteria of brief or attenuated psychotic symptoms, or first-degree family history with functional decline) is outlined. The first patients recruited are compared with non-patient samples on cognitive and personality factors; an interim analysis of transition rate is reported. Results: Cases (n=31) were recruited mainly from primary care. Of the 23 high-risk patients monitored for 6-12 months, 5 (22%) made the transition to psychosis. The high-risk group scored significantly higher than non-patients on measures of schizotypy, metacognitive beliefs and dysfunctional self-schemas (sociotropy). Conclusions: The findings validate the methods of identifying individuals at high risk of experiencing a psychotic episode. Compared with non-patient controls, the cases showed dysfunctional metacognitive beliefs and self-schemas. Declaration of interest: Funded by North-West NHS Executive.
    Original languageEnglish
    Pages (from-to)s78-s84
    JournalBritish Journal of Psychiatry
    Volume181
    Issue number43
    Publication statusPublished - Sep 2002

    Keywords

    • Adult
    • Cognition
    • Cognitive Therapy
    • Female
    • Human
    • Male
    • diagnosis: Psychotic Disorders
    • Risk Factors
    • Self Concept
    • Support, Non-U.S. Gov't

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