Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: Effects on circulating eicosanoids and cardiovascular risk factors

Christine Dawczynski; Karen A. Massey; Christina Ness; Michael Kiehntopf; Stefanie Stepanow; Matthias Platzer; Michael Grün; Anna Nicolaou; Gerhard Jahreis

doi:10.1016/j.clnu.2012.12.010

Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: Effects on circulating eicosanoids and cardiovascular risk factors

Christine Dawczynski, Karen A. Massey, Christina Ness, Michael Kiehntopf, Stefanie Stepanow, Matthias Platzer, Michael Grün, Anna Nicolaou, Gerhard Jahreis

Research output: Contribution to journal › Article › peer-review

Abstract

Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG≥1.7mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3g n-3 LC-PUFA/d for a period of 10wks. Blood samples were taken at the beginning and the end of the study period. Results: Following daily intake of 3g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE3, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P

Original language	English
Pages (from-to)	686-696
Number of pages	10
Journal	Clinical Nutrition
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.clnu.2012.12.010
Publication status	Published - Oct 2013

Keywords

Blood lipids
Cytokines
Dairy products
Eicosanoids
N-3 LC-PUFA

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10.1016/j.clnu.2012.12.010

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title = "Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: Effects on circulating eicosanoids and cardiovascular risk factors",

abstract = "Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG≥1.7mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3g n-3 LC-PUFA/d for a period of 10wks. Blood samples were taken at the beginning and the end of the study period. Results: Following daily intake of 3g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE3, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P",

keywords = "Blood lipids, Cytokines, Dairy products, Eicosanoids, N-3 LC-PUFA",

author = "Christine Dawczynski and Massey, {Karen A.} and Christina Ness and Michael Kiehntopf and Stefanie Stepanow and Matthias Platzer and Michael Gr{\"u}n and Anna Nicolaou and Gerhard Jahreis",

year = "2013",

month = oct,

doi = "10.1016/j.clnu.2012.12.010",

language = "English",

volume = "32",

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T1 - Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: Effects on circulating eicosanoids and cardiovascular risk factors

AU - Dawczynski, Christine

AU - Massey, Karen A.

AU - Ness, Christina

AU - Kiehntopf, Michael

AU - Stepanow, Stefanie

AU - Platzer, Matthias

AU - Grün, Michael

AU - Nicolaou, Anna

AU - Jahreis, Gerhard

PY - 2013/10

Y1 - 2013/10

N2 - Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG≥1.7mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3g n-3 LC-PUFA/d for a period of 10wks. Blood samples were taken at the beginning and the end of the study period. Results: Following daily intake of 3g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE3, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P

AB - Background & aims: The study examined the value of n-3 LC-PUFA-enriched yogurt as means of improving cardiovascular health. Design: Fifty three mildly hypertriacylglycerolemic subjects (TAG≥1.7mmol/L) participated in a randomized, placebo-controlled, double-blind, parallel designed study. The subjects consumed 1) control yoghurt; 2) yoghurt enriched with 0.8g n-3 LC-PUFA/d; or 3) yoghurt enriched with 3g n-3 LC-PUFA/d for a period of 10wks. Blood samples were taken at the beginning and the end of the study period. Results: Following daily intake of 3g n-3 LC-PUFA for 10 weeks, n-3 LC-PUFA levels increased significantly in plasma and red blood cells (RBC) with concomitant increase in the EPA-derived mediators (PGE3, 12-, 15-, 18-HEPE) in plasma whilst cardiovascular risk factors such as HDL, TAG, AA/EPA ratio, and n-3 index were improved (P

KW - Blood lipids

KW - Cytokines

KW - Dairy products

KW - Eicosanoids

KW - N-3 LC-PUFA

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DO - 10.1016/j.clnu.2012.12.010

M3 - Article

SN - 0261-5614

VL - 32

SP - 686

EP - 696

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 5

ER -

Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: Effects on circulating eicosanoids and cardiovascular risk factors

Abstract

Keywords

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