Rapid chloride analysis using miniaturised isotachophoresis

Jeff E. Prest; Sara J. Baldock; Peter R. Fielden; Nicholas J. Goddard; Stephan Mohr; Bernard J. Treves Brown

doi:10.1016/j.chroma.2005.11.030

Rapid chloride analysis using miniaturised isotachophoresis

Jeff E. Prest, Sara J. Baldock, Peter R. Fielden, Nicholas J. Goddard, Stephan Mohr, Bernard J. Treves Brown

Research output: Contribution to journal › Article › peer-review

Abstract

A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l-1. © 2005 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	183-187
Number of pages	4
Journal	Journal of Chromatography A
Volume	1119
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2005.11.030
Publication status	Published - 30 Jun 2006

Keywords

Chip
Chloride analysis
Conductivity detection
Isotachophoresis
Microdevice
Miniaturisation

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10.1016/j.chroma.2005.11.030

Cite this

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title = "Rapid chloride analysis using miniaturised isotachophoresis",

abstract = "A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l-1. {\textcopyright} 2005 Elsevier B.V. All rights reserved.",

keywords = "Chip, Chloride analysis, Conductivity detection, Isotachophoresis, Microdevice, Miniaturisation",

author = "Prest, {Jeff E.} and Baldock, {Sara J.} and Fielden, {Peter R.} and Goddard, {Nicholas J.} and Stephan Mohr and {Treves Brown}, {Bernard J.}",

year = "2006",

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doi = "10.1016/j.chroma.2005.11.030",

language = "English",

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TY - JOUR

T1 - Rapid chloride analysis using miniaturised isotachophoresis

AU - Prest, Jeff E.

AU - Baldock, Sara J.

AU - Fielden, Peter R.

AU - Goddard, Nicholas J.

AU - Mohr, Stephan

AU - Treves Brown, Bernard J.

PY - 2006/6/30

Y1 - 2006/6/30

N2 - A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l-1. © 2005 Elsevier B.V. All rights reserved.

AB - A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l-1. © 2005 Elsevier B.V. All rights reserved.

KW - Chip

KW - Chloride analysis

KW - Conductivity detection

KW - Isotachophoresis

KW - Microdevice

KW - Miniaturisation

U2 - 10.1016/j.chroma.2005.11.030

DO - 10.1016/j.chroma.2005.11.030

M3 - Article

SN - 1873-3778

VL - 1119

SP - 183

EP - 187

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 1-2

ER -

Rapid chloride analysis using miniaturised isotachophoresis

Abstract

Keywords

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