Rapid chloride analysis using miniaturised isotachophoresis

Jeff E. Prest, Sara J. Baldock, Peter R. Fielden, Nicholas J. Goddard, Stephan Mohr, Bernard J. Treves Brown

    Research output: Contribution to journalArticlepeer-review


    A new design of miniaturised separation device for performing isotachophoresis (ITP) has been produced. The device contains a simple arrangement of channels comprising a single separation channel with a 'double T' injection geometry. The device was produced in poly(methyl methacrylate) and incorporates an on-column conductivity detector. A new electrolyte system was developed to enable the rapid determination of chloride to be made. This electrolyte system uses a leading ion of 3.5 mM nitrate at pH 3.0 with 0.5 mM indium(III) added as a complexing agent. Use of this electrolyte system with the new separation device allowed chloride samples to be analysed in under 100 s, with a limit of detection (LOD) calculated to be 2.2 mg l-1. © 2005 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)183-187
    Number of pages4
    JournalJournal of Chromatography A
    Issue number1-2
    Publication statusPublished - 30 Jun 2006


    • Chip
    • Chloride analysis
    • Conductivity detection
    • Isotachophoresis
    • Microdevice
    • Miniaturisation


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