Rapid non-invasive diagnosis of herpes encephalitis

P. E. Klapper; I. Laing; M. Longson

doi:10.1016/S0140-6736(81)92744-6

Rapid non-invasive diagnosis of herpes encephalitis

P. E. Klapper^*, I. Laing, M. Longson

^*Corresponding author for this work

Division of Evolution, Infection and Genomics

Manchester Royal Infirmary Laboratory

Research output: Contribution to journal › Article › peer-review

Abstract

A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. When combined with the measurement of albumin in serum and CSF an accurate diagnostic index was obtained in twenty-four out of twenty-six patients. Out often patients tested before day 10 of neurological illness, five had positive diagnostic indices. Three patients with negative indices before day 10 had positive indices when re-tested later.

Original language	English
Pages (from-to)	607-609
Number of pages	3
Journal	The Lancet
Volume	318
Issue number	8247
DOIs	https://doi.org/10.1016/S0140-6736(81)92744-6
Publication status	Published - 19 Sept 1981

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title = "Rapid non-invasive diagnosis of herpes encephalitis",

abstract = "A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. When combined with the measurement of albumin in serum and CSF an accurate diagnostic index was obtained in twenty-four out of twenty-six patients. Out often patients tested before day 10 of neurological illness, five had positive diagnostic indices. Three patients with negative indices before day 10 had positive indices when re-tested later.",

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AU - Laing, I.

AU - Longson, M.

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N2 - A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. When combined with the measurement of albumin in serum and CSF an accurate diagnostic index was obtained in twenty-four out of twenty-six patients. Out often patients tested before day 10 of neurological illness, five had positive diagnostic indices. Three patients with negative indices before day 10 had positive indices when re-tested later.

AB - A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. When combined with the measurement of albumin in serum and CSF an accurate diagnostic index was obtained in twenty-four out of twenty-six patients. Out often patients tested before day 10 of neurological illness, five had positive diagnostic indices. Three patients with negative indices before day 10 had positive indices when re-tested later.

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Rapid non-invasive diagnosis of herpes encephalitis

Abstract

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