Rapid non-invasive diagnosis of herpes encephalitis

P. E. Klapper, I. Laing, M. Longson

Research output: Contribution to journalArticlepeer-review


A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. When combined with the measurement of albumin in serum and CSF an accurate diagnostic index was obtained in twenty-four out of twenty-six patients. Out often patients tested before day 10 of neurological illness, five had positive diagnostic indices. Three patients with negative indices before day 10 had positive indices when re-tested later.

Original languageEnglish
Pages (from-to)607-609
Number of pages3
JournalThe Lancet
Issue number8247
Publication statusPublished - 19 Sept 1981


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