Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

E Papadakis; A Malliri; S Linardopoulos; H Karaiossifidi; J Field; D Spandidos

Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

E Papadakis, A Malliri, S Linardopoulos, H Karaiossifidi, J Field, D Spandidos

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p

Original language	English
Journal	International Journal of Oncology
Volume	1
Issue number	4
Publication status	Published - Sept 1992

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title = "Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.",

abstract = "Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46\% and ras p21 was over-expressed in 85\% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p",

author = "E Papadakis and A Malliri and S Linardopoulos and H Karaiossifidi and J Field and D Spandidos",

year = "1992",

month = sep,

language = "English",

volume = "1",

journal = "International Journal of Oncology",

issn = "1019-6439",

publisher = "Spandidos Publications",

number = "4",

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TY - JOUR

T1 - Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

AU - Papadakis, E

AU - Malliri, A

AU - Linardopoulos, S

AU - Karaiossifidi, H

AU - Field, J

AU - Spandidos, D

PY - 1992/9

Y1 - 1992/9

N2 - Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p

AB - Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. Fifteen cases of benign lessions were also assessed for both ras p21 and p53 expression; all were found to have negative staining. p53 over-expression was found to correlate with a poor prognosis in both the tumor specimens (p

M3 - Article

C2 - 21584560

SN - 1019-6439

VL - 1

JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 4

ER -

Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

Abstract

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