TY - JOUR
T1 - Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet
AU - Oceandy, Delvac
AU - Cartwright, Elizabeth J.
AU - Neyses, Ludwig
PY - 2009/11
Y1 - 2009/11
N2 - The close relationship between signaling pathways regulating tumor growth and cardiac hypertrophy has attracted considerable interest. Although the involvement of proto-oncogenes in positively modulating myocardial hypertrophy has long been recognized, little is known about factors that counterregulate them. In this article, we review the novel tumor suppressor Ras-association domain family protein isoform 1A (RASSF1A), which strongly inhibits the prohypertrophic Ras-Raf1-ERK1/2 pathway in the heart. RASSF1A interacts with a number of important signaling molecules regulating cell growth, survival, and apoptosis; therefore, it serves as a key adaptor molecule that integrates the upstream stimuli and transduces them to the selective downstream effectors. © 2009 Elsevier Inc.
AB - The close relationship between signaling pathways regulating tumor growth and cardiac hypertrophy has attracted considerable interest. Although the involvement of proto-oncogenes in positively modulating myocardial hypertrophy has long been recognized, little is known about factors that counterregulate them. In this article, we review the novel tumor suppressor Ras-association domain family protein isoform 1A (RASSF1A), which strongly inhibits the prohypertrophic Ras-Raf1-ERK1/2 pathway in the heart. RASSF1A interacts with a number of important signaling molecules regulating cell growth, survival, and apoptosis; therefore, it serves as a key adaptor molecule that integrates the upstream stimuli and transduces them to the selective downstream effectors. © 2009 Elsevier Inc.
U2 - 10.1016/j.tcm.2010.02.008
DO - 10.1016/j.tcm.2010.02.008
M3 - Article
C2 - 20447568
SN - 1050-1738
VL - 19
SP - 262
EP - 267
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 8
ER -
