Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

N. O'Leary; P. H. Artes; D. M. Hutchison; M. T. Nicolela; B. C. Chauhan

doi:Doi 10.1038/Eye.2012.202

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

N. O'Leary, P. H. Artes, D. M. Hutchison, M. T. Nicolela, B. C. Chauhan

Research output: Contribution to journal › Article › peer-review

Abstract

PurposeTo examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and time-domain optical coherence tomography (OCT).MethodsSixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixed-effects models.ResultsThe median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P=0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (P

Original language	English
Pages (from-to)	1554-1562
Number of pages	8
Journal	Eye
Volume	26
Issue number	12
DOIs	https://doi.org/Doi 10.1038/Eye.2012.202
Publication status	Published - Dec 2012

Keywords

glaucoma
optical coherence tomography
progression
retinal nerve fibre layer
scanning laser polarimetry

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Doi 10.1038/Eye.2012.202

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title = "Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects",

abstract = "PurposeTo examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and time-domain optical coherence tomography (OCT).MethodsSixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixed-effects models.ResultsThe median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P=0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (P",

keywords = "glaucoma, optical coherence tomography, progression, retinal nerve fibre layer, scanning laser polarimetry",

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AU - Artes, P. H.

AU - Hutchison, D. M.

AU - Nicolela, M. T.

AU - Chauhan, B. C.

N1 - 055WB Times Cited:0 Cited References Count:52

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N2 - PurposeTo examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and time-domain optical coherence tomography (OCT).MethodsSixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixed-effects models.ResultsThe median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P=0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (P

AB - PurposeTo examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and time-domain optical coherence tomography (OCT).MethodsSixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixed-effects models.ResultsThe median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P=0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (P

KW - glaucoma

KW - optical coherence tomography

KW - progression

KW - retinal nerve fibre layer

KW - scanning laser polarimetry

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JF - Eye

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Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

Abstract

Keywords

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