Rationale and design of the United Kingdom Heart Failure with Preserved Ejection Fraction Registry

The UK HFpEF Collaborative Group, et al.

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Heart failure with preserved ejection fraction (HFpEF) is a common, heterogeneous syndrome that remains imprecisely defined and consequently has limited treatment options and poor outcomes.

Methods: The United Kingdom Heart Failure with Preserved Ejection Fraction Registry (UK HFpEF) is a prospective data-enabled cohort and platform study. The study will develop a large, highly characterised cohort of patients with HFpEF. A biobank will be established. Deep clinical phenotyping, imaging, multi-omics and centrally-held national electronic health record data will be integrated at scale, in order to reclassify HFpEF into distinct subgroups, improve understanding of disease mechanisms, and identify new biological pathways and molecular targets. Together, these will form the basis for developing diagnostics and targeted therapeutics specific to subgroups. It will be a platform for more effective and efficient trials, focusing on subgroups in whom targeted interventions are expected to be effective, with consent in place to facilitate rapid recruitment, and linkage for follow-up. Patients with a diagnosis of HFpEF made by a heart failure specialist, who have had natriuretic peptide levels measured, and a left ventricular ejection fraction > 40%, are eligible. Patients with an ejection fraction between 40 to 49% will be limited to no more than 25% of the cohort.

Conclusions: UK HFpEF will develop a rich, multimodal data resource to enable the identification of disease endotypes and develop more effective diagnostic strategies, precise risk stratification and targeted therapeutics.
Original languageEnglish
JournalHeart
DOIs
Publication statusPublished - 12 Oct 2023

Keywords

  • Heart failure with preserved ejection fraction
  • personalised medicine
  • cohort
  • platform

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