Re-irradiation for painful bone metastases - a systematic review

Erin Wong; Peter Hoskin; Gillian Bedard; Michael Poon; Liang Zeng; Henry Lam; Horia Vulpe; May Tsao; Natalie Pulenzas; Edward Chow

doi:10.1016/j.radonc.2013.09.004

Re-irradiation for painful bone metastases - a systematic review

Erin Wong, Peter Hoskin, Gillian Bedard, Michael Poon, Liang Zeng, Henry Lam, Horia Vulpe, May Tsao, Natalie Pulenzas, Edward Chow

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

The purpose of this review was to determine the efficacy of re-irradiation in patients with bone metastases. A literature search was conducted in Ovid Medline, OldMedline, Embase, Embase Classic, and Cochrane Central Register of Controlled Trials using relevant subject headings and keywords such as bone metastases, radiotherapy and palliative care. The resulting articles were sorted for inclusion for palliative external beam radiation retreatment response rate data. The literature search produced 2164 references and 15 articles were included in the final selection. Complete, partial and overall response rates were calculated to be 20%, 50% and 68%, respectively. Information on treatment toxicities was scarce. The efficacy of re-irradiation is comparable to initial radiation treatment. However, aspects of re-irradiation treatment including dose fractionation, related adverse events and toxicities require further corroboration.

Original language	English
Pages (from-to)	61-70
Number of pages	10
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/j.radonc.2013.09.004
Publication status	Published - Jan 2014

Keywords

Bone Neoplasms/complications
Dose Fractionation, Radiation
Humans
Pain/etiology
Palliative Care/methods
Randomized Controlled Trials as Topic
Retreatment

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.radonc.2013.09.004

Cite this

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title = "Re-irradiation for painful bone metastases - a systematic review",

abstract = "The purpose of this review was to determine the efficacy of re-irradiation in patients with bone metastases. A literature search was conducted in Ovid Medline, OldMedline, Embase, Embase Classic, and Cochrane Central Register of Controlled Trials using relevant subject headings and keywords such as bone metastases, radiotherapy and palliative care. The resulting articles were sorted for inclusion for palliative external beam radiation retreatment response rate data. The literature search produced 2164 references and 15 articles were included in the final selection. Complete, partial and overall response rates were calculated to be 20%, 50% and 68%, respectively. Information on treatment toxicities was scarce. The efficacy of re-irradiation is comparable to initial radiation treatment. However, aspects of re-irradiation treatment including dose fractionation, related adverse events and toxicities require further corroboration. ",

keywords = "Bone Neoplasms/complications, Dose Fractionation, Radiation, Humans, Pain/etiology, Palliative Care/methods, Randomized Controlled Trials as Topic, Retreatment",

author = "Erin Wong and Peter Hoskin and Gillian Bedard and Michael Poon and Liang Zeng and Henry Lam and Horia Vulpe and May Tsao and Natalie Pulenzas and Edward Chow",

year = "2014",

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doi = "10.1016/j.radonc.2013.09.004",

language = "English",

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pages = "61--70",

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T1 - Re-irradiation for painful bone metastases - a systematic review

AU - Wong, Erin

AU - Hoskin, Peter

AU - Bedard, Gillian

AU - Poon, Michael

AU - Zeng, Liang

AU - Lam, Henry

AU - Vulpe, Horia

AU - Tsao, May

AU - Pulenzas, Natalie

AU - Chow, Edward

PY - 2014/1

Y1 - 2014/1

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AB - The purpose of this review was to determine the efficacy of re-irradiation in patients with bone metastases. A literature search was conducted in Ovid Medline, OldMedline, Embase, Embase Classic, and Cochrane Central Register of Controlled Trials using relevant subject headings and keywords such as bone metastases, radiotherapy and palliative care. The resulting articles were sorted for inclusion for palliative external beam radiation retreatment response rate data. The literature search produced 2164 references and 15 articles were included in the final selection. Complete, partial and overall response rates were calculated to be 20%, 50% and 68%, respectively. Information on treatment toxicities was scarce. The efficacy of re-irradiation is comparable to initial radiation treatment. However, aspects of re-irradiation treatment including dose fractionation, related adverse events and toxicities require further corroboration.

KW - Bone Neoplasms/complications

KW - Dose Fractionation, Radiation

KW - Humans

KW - Pain/etiology

KW - Palliative Care/methods

KW - Randomized Controlled Trials as Topic

KW - Retreatment

U2 - 10.1016/j.radonc.2013.09.004

DO - 10.1016/j.radonc.2013.09.004

M3 - Review article

C2 - 24094630

SN - 0167-8140

VL - 110

SP - 61

EP - 70

JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

IS - 1

ER -

Re-irradiation for painful bone metastases - a systematic review

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

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Cite this