Re-Irradiation of Recurrent Non-Small Cell Lung Cancer

Benjamin Hunter, Cathryn Crockett, Corinne Faivre-Finn, Crispin Hiley, Ahmed Salem

Research output: Contribution to journalReview articlepeer-review


Locoregional recurrence occurs in 10%-30% of non-small cell lung cancer (NSCLC) after treatment with definitive (chemo)radiotherapy. Re-irradiation is the main curative-intent treatment option for these patients; however, it represents a therapeutic challenge for thoracic radiation oncologists. Re-irradiation practices are variable worldwide with lack of agreement on the optimal dose or the cumulative maximum dose acceptable for critical organs. The role of re-irradiation in NSCLC is also not clearly defined in the era of immunotherapy. In this review, we will present published and on-going re-irradiation studies for recurrent NSCLC. We will appraise available evidence for critical organ dose constraints and provide a framework for future therapeutic approaches and trials.

Original languageEnglish
Pages (from-to)124-132
Number of pages9
JournalSeminars in Radiation Oncology
Issue number2
Publication statusPublished - Apr 2021


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