Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

P. Sudhindra; S. Ajay Sharma; Nilmadhab Roy; Prithvi Moharana; Priyankar Paira

doi:10.1016/j.poly.2020.114827

Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

P. Sudhindra, S. Ajay Sharma, Nilmadhab Roy, Prithvi Moharana, Priyankar Paira^*

^*Corresponding author for this work

Vellore Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

Due to these limitations of platinum-based drugs, it has now become a challenge for researchers to find out a potential scaffold furnished with indispensable properties like enhanced selectivity (less toxicity) and target specificity. In the past two decades, ruthenium-based scaffolds have become a matter of keen interest to scientist due to their unique properties. So, in this review, we have focused our attention in dealing with the advances in various types of ruthenium complexes in the anticancer application based on their cytotoxicity profiles, cellular uptake, biological targets and mechanism of action.

Original language	English
Article number	114827
Journal	Polyhedron
Volume	192
DOIs	https://doi.org/10.1016/j.poly.2020.114827
Publication status	Published - 1 Dec 2020
Externally published	Yes

Keywords

Binuclear Ru complex
DNA targeting
Mechanism of action
Organoruthenium
ROS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.poly.2020.114827

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title = "Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review",

abstract = "Due to these limitations of platinum-based drugs, it has now become a challenge for researchers to find out a potential scaffold furnished with indispensable properties like enhanced selectivity (less toxicity) and target specificity. In the past two decades, ruthenium-based scaffolds have become a matter of keen interest to scientist due to their unique properties. So, in this review, we have focused our attention in dealing with the advances in various types of ruthenium complexes in the anticancer application based on their cytotoxicity profiles, cellular uptake, biological targets and mechanism of action.",

keywords = "Binuclear Ru complex, DNA targeting, Mechanism of action, Organoruthenium, ROS",

author = "P. Sudhindra and {Ajay Sharma}, S. and Nilmadhab Roy and Prithvi Moharana and Priyankar Paira",

note = "Funding Information: The authors gratefully acknowledge VIT for providing {\textquoteleft}VIT SEED GRANT{\textquoteright}, Vellore for the support through Seed Grant for Research. We acknowledge DST, New Delhi, India for DST-FIST project. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.poly.2020.114827",

language = "English",

volume = "192",

journal = "Polyhedron",

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TY - JOUR

T1 - Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs

T2 - A review

AU - Sudhindra, P.

AU - Ajay Sharma, S.

AU - Roy, Nilmadhab

AU - Moharana, Prithvi

AU - Paira, Priyankar

N1 - Funding Information: The authors gratefully acknowledge VIT for providing ‘VIT SEED GRANT’, Vellore for the support through Seed Grant for Research. We acknowledge DST, New Delhi, India for DST-FIST project. Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Due to these limitations of platinum-based drugs, it has now become a challenge for researchers to find out a potential scaffold furnished with indispensable properties like enhanced selectivity (less toxicity) and target specificity. In the past two decades, ruthenium-based scaffolds have become a matter of keen interest to scientist due to their unique properties. So, in this review, we have focused our attention in dealing with the advances in various types of ruthenium complexes in the anticancer application based on their cytotoxicity profiles, cellular uptake, biological targets and mechanism of action.

AB - Due to these limitations of platinum-based drugs, it has now become a challenge for researchers to find out a potential scaffold furnished with indispensable properties like enhanced selectivity (less toxicity) and target specificity. In the past two decades, ruthenium-based scaffolds have become a matter of keen interest to scientist due to their unique properties. So, in this review, we have focused our attention in dealing with the advances in various types of ruthenium complexes in the anticancer application based on their cytotoxicity profiles, cellular uptake, biological targets and mechanism of action.

KW - Binuclear Ru complex

KW - DNA targeting

KW - Mechanism of action

KW - Organoruthenium

KW - ROS

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U2 - 10.1016/j.poly.2020.114827

DO - 10.1016/j.poly.2020.114827

M3 - Review article

AN - SCOPUS:85092535202

SN - 0277-5387

VL - 192

JO - Polyhedron

JF - Polyhedron

M1 - 114827

ER -

Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

Abstract

Keywords

UN SDGs

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