TY - JOUR
T1 - Recent advances in short peptide self-assembly
T2 - from rational design to novel applications
AU - Hu, Xuzhi
AU - Liao, Mingrui
AU - Gong, Haoning
AU - Zhang, Lin
AU - Cox, Henry
AU - Waigh, Thomas A.
AU - Lu, Jian R.
N1 - Funding Information:
The authors thank the University of Manchester for support in the form of an overseas research studentship to X.H., M.L., H.G., and L.Z., an award from China Scholarship Council to M.L., L.Z., and H.G., and research fund support from Syngenta to X.H. The authors thank ISIS Neutron Facility, STFC and Institut Laue Langevin, Grenoble for awards of neutron beam times. This work also benefited from the grant support from EPSRC ( EP/F062966/1 ), Innovate UK ( KTP009043 ), and a Marie Curie Fellowship ITN grant (grant number 608184 ) under SNAL (Small nano-objects for alteration of lipid-bilayers).
Funding Information:
The authors thank the University of Manchester for support in the form of an overseas research studentship to X.H. M.L. H.G. and L.Z. an award from China Scholarship Council to M.L. L.Z. and H.G. and research fund support from Syngenta to X.H. The authors thank ISIS Neutron Facility, STFC and Institut Laue Langevin, Grenoble for awards of neutron beam times. This work also benefited from the grant support from EPSRC (EP/F062966/1), Innovate UK (KTP009043), and a Marie Curie Fellowship ITN grant (grant number 608184) under SNAL (Small nano-objects for alteration of lipid-bilayers).
Publisher Copyright:
© 2019
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Owing to their structural simplicity and robust self-assembled nanostructures, short peptides prove to be an ideal system to explore the physical processes of self-assembly, hydrogels, semi-flexible polymers, quenched disorder, and reptation. Rational design in peptide sequences facilitates cost-effective manufacturing, but the huge number of possible peptides has imposed obstacles for their characterization to establish functional connections to the primary, secondary, and tertiary structures. This review aims to cover recent advances in the self-assembly of designed short peptides, with a focus on physical driving forces, design rules, characterization methods, and exemplar applications. Super-resolution microscopy in combination with modern image analysis have been applied to quantify the structure and dynamics of peptide hydrogels, while small-angle neutron scattering and solid-state nuclear magnetic resonance continue to provide valuable information on structures over complementary length scales. Short peptides are attractive in biomedicine and nanotechnology, e.g., as antimicrobials, anticancer agents, vehicles for controlled drug release, peptide bioelectronics, and responsive cell culture materials.
AB - Owing to their structural simplicity and robust self-assembled nanostructures, short peptides prove to be an ideal system to explore the physical processes of self-assembly, hydrogels, semi-flexible polymers, quenched disorder, and reptation. Rational design in peptide sequences facilitates cost-effective manufacturing, but the huge number of possible peptides has imposed obstacles for their characterization to establish functional connections to the primary, secondary, and tertiary structures. This review aims to cover recent advances in the self-assembly of designed short peptides, with a focus on physical driving forces, design rules, characterization methods, and exemplar applications. Super-resolution microscopy in combination with modern image analysis have been applied to quantify the structure and dynamics of peptide hydrogels, while small-angle neutron scattering and solid-state nuclear magnetic resonance continue to provide valuable information on structures over complementary length scales. Short peptides are attractive in biomedicine and nanotechnology, e.g., as antimicrobials, anticancer agents, vehicles for controlled drug release, peptide bioelectronics, and responsive cell culture materials.
KW - Short peptides
KW - Self-assembly
KW - Non-covalent interactions
KW - Molecular design
KW - Nanostructures
KW - Characterization techniques
KW - STORM
KW - SANS
KW - Hydrogels
UR - https://doi.org/10.1016/j.cocis.2019.08.003
UR - http://www.scopus.com/inward/record.url?scp=85073077557&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/5c4ed58c-edbb-3345-ae65-8b8258d943be/
U2 - 10.1016/j.cocis.2019.08.003
DO - 10.1016/j.cocis.2019.08.003
M3 - Review article
SN - 1359-0294
VL - 45
SP - 1
EP - 13
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
ER -