Recent advances in the diagnosis and management of pre-eclampsia [version 1; referees: 2 approved]

Kate Duhig, Brooke Vandermolen, Andrew H Shennan

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-eclampsia is a leading cause of maternal mortality, responsible annually for over 60,000 maternal deaths around the globe. Pre-eclampsia is a multisystem disease featuring hypertension, proteinuria, and renal, hepatic, and neurological involvement. Diagnosis is often elusive, as clinical presentation is highly variable. Even those with severe disease can remain asymptomatic. Angiogenic factors are emerging as having a role in the diagnosis of pre-eclampsia and in prognostication of established disease. In this article, we summarize new developments and focus on angiogenic biomarkers for prediction of disease onset. We also discuss recent advances in management strategies for patients with hypertensive disorders of pregnancy.
Original languageEnglish
Article number242
Pages (from-to)1-9
Number of pages9
JournalF1000Research
Volume7
DOIs
Publication statusPublished - 28 Feb 2018

Keywords

  • pre-eclampsia
  • hypertensive disorders
  • diagnosis
  • PlGF
  • angiogenic biomarkers

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