Recent advances in urocanic acid photochemistry, photobiology and photoimmunology

Neil K. Gibbs, Joanne Tye, Mary Norval

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Urocanic acid (UCA), produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR). Originally thought to be a 'natural sunscreen', studies conducted a quarter of a century ago proposed that UCA may be a chromophore for the immunosuppression that follows exposure to UVR. With its intriguing photochemistry, its role in immunosuppression and skin cancer development, and skin barrier function, UCA continues to be the subject of intense research effort. This review summarises the photochemical, photobiological and photoimmunological findings regarding UCA, published since 1998. © The Royal Society of Chemistry and Owner Societies.
    Original languageEnglish
    Pages (from-to)655-667
    Number of pages12
    JournalPhotochemical and Photobiological Sciences
    Volume7
    Issue number6
    DOIs
    Publication statusPublished - 2008

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