Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

Meng Zhang; Jukka P Matinlinna; James K H Tsoi; Wenlong Liu; Xu Cui; William W Lu; Haobo Pan

doi:10.1016/j.jot.2019.09.005

Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

Meng Zhang
, Jukka P Matinlinna
, James K H Tsoi
, Wenlong Liu
, Xu Cui
, William W Lu
, Haobo Pan^*

^*Corresponding author for this work

Division of Dentistry (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years.

The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Journal of orthopaedic translation
Volume	22
Early online date	8 Oct 2019
DOIs	https://doi.org/10.1016/j.jot.2019.09.005
Publication status	Published - May 2020

Keywords

allograft
artificial material
autograft
biomaterial
long-bone segmental defect reconstruction
tissue engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jot.2019.09.005

Cite this

@article{7bce196fb51b4eb0aa9d237a82a3988e,

title = "Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview",

abstract = "Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.",

keywords = "allograft, artificial material, autograft, biomaterial, long-bone segmental defect reconstruction, tissue engineering",

author = "Meng Zhang and Matinlinna, \{Jukka P\} and Tsoi, \{James K H\} and Wenlong Liu and Xu Cui and Lu, \{William W\} and Haobo Pan",

note = "{\textcopyright} 2019 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.",

year = "2020",

month = may,

doi = "10.1016/j.jot.2019.09.005",

language = "English",

volume = "22",

pages = "26--33",

journal = "Journal of orthopaedic translation",

issn = "2214-031X",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Recent developments in biomaterials for long-bone segmental defect reconstruction

T2 - A narrative overview

AU - Zhang, Meng

AU - Matinlinna, Jukka P

AU - Tsoi, James K H

AU - Liu, Wenlong

AU - Cui, Xu

AU - Lu, William W

AU - Pan, Haobo

PY - 2020/5

Y1 - 2020/5

N2 - Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.

AB - Reconstruction of long-bone segmental defects (LBSDs) has been one of the biggest challenges in orthopaedics. Biomaterials for the reconstruction are required to be strong, osteoinductive, osteoconductive, and allowing for fast angiogenesis, without causing any immune rejection or disease transmission. There are four main types of biomaterials including autograft, allograft, artificial material, and tissue-engineered bone. Remarkable progress has been made in LBSD reconstruction biomaterials in the last ten years. The translational potential of this article: Our aim is to summarize recent developments in the divided four biomaterials utilized in the LBSD reconstruction to provide the clinicians with new information and comprehension from the biomaterial point of view.

KW - allograft

KW - artificial material

KW - autograft

KW - biomaterial

KW - long-bone segmental defect reconstruction

KW - tissue engineering

U2 - 10.1016/j.jot.2019.09.005

DO - 10.1016/j.jot.2019.09.005

M3 - Review article

C2 - 32440496

SN - 2214-031X

VL - 22

SP - 26

EP - 33

JO - Journal of orthopaedic translation

JF - Journal of orthopaedic translation

ER -

Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview

Abstract

Keywords

UN SDGs

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