Recent developments in the transcriptional regulation of cytolytic effector cells

Laurie H. Glimcher, Michael J. Townsend, Brandon M. Sullivan, Graham M. Lord

Research output: Contribution to journalReview articlepeer-review

Abstract

Transcription factors have a profound influence on both the differentiation and effector function of cells of the immune system. T-bet controls the cytotoxicity of CD8+ T cells and the production of interferon-γ, and it also affects the development and function of natural killer cells and natural killer T cells. Other factors such as eomesodermin, MEF, ETS1 and members of the interferon-regulatory factor family also contribute to the effector function of immune cells. In this review, we focus on recent studies that have shed light on the transcriptional mechanisms that regulate cellular effector function in the immune system.
Original languageEnglish
Pages (from-to)900-911
JournalNature Reviews Immunology
Volume4
Issue number11
DOIs
Publication statusPublished - 1 Nov 2004

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