Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

M. M. Seenath; D. Roberts; C. Cawthorne; M. P. Saunders; G. R. Armstrong; S. T. O'Dwyer; I. J. Stratford; C. Dive; A. G. Renehan

doi:10.1038/sj.bjc.6604474

Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

M. M. Seenath, D. Roberts, C. Cawthorne, M. P. Saunders, G. R. Armstrong, S. T. O'Dwyer, I. J. Stratford, C. Dive, A. G. Renehan

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. © 2008 Cancer Research UK All rights reserved.

Original language	English
Pages (from-to)	459-463
Number of pages	4
Journal	British Journal of Cancer
Volume	99
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjc.6604474
Publication status	Published - 5 Aug 2008

Keywords

Bid
Colorectal cancer
HIF-1α
Tumour hypoxia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6604474

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Seenath, M. M., Roberts, D., Cawthorne, C., Saunders, M. P., Armstrong, G. R., O'Dwyer, S. T., Stratford, I. J., Dive, C., & Renehan, A. G. (2008). Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer. British Journal of Cancer, 99(3), 459-463. https://doi.org/10.1038/sj.bjc.6604474

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title = "Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer",

abstract = "Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. {\textcopyright} 2008 Cancer Research UK All rights reserved.",

keywords = "Bid, Colorectal cancer, HIF-1α, Tumour hypoxia",

author = "Seenath, {M. M.} and D. Roberts and C. Cawthorne and Saunders, {M. P.} and Armstrong, {G. R.} and O'Dwyer, {S. T.} and Stratford, {I. J.} and C. Dive and Renehan, {A. G.}",

year = "2008",

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AU - Seenath, M. M.

AU - Roberts, D.

AU - Cawthorne, C.

AU - Saunders, M. P.

AU - Armstrong, G. R.

AU - O'Dwyer, S. T.

AU - Stratford, I. J.

AU - Dive, C.

AU - Renehan, A. G.

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N2 - Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. © 2008 Cancer Research UK All rights reserved.

AB - Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1α nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. © 2008 Cancer Research UK All rights reserved.

KW - Bid

KW - Colorectal cancer

KW - HIF-1α

KW - Tumour hypoxia

U2 - 10.1038/sj.bjc.6604474

DO - 10.1038/sj.bjc.6604474

M3 - Article

SN - 0007-0920

VL - 99

SP - 459

EP - 463

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer

Abstract

Keywords

UN SDGs

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