Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer.

M Seenath; DL Roberts; C Cawthorne; M Saunders; G Armstrong; S O'Dwyer; IJ Stratford; C Dive; Andrew Renehan

Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer.

M Seenath, DL Roberts, C Cawthorne, M Saunders, G Armstrong, S O'Dwyer, IJ Stratford, C Dive, Andrew Renehan

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.British Journal of Cancer (2008) 99, 459-463. doi:10.1038/sj.bjc.6604474 www.bjcancer.com Published online 22 July 2008.

Original language	English
Journal	Br J Cancer
Volume	99( 3)
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{59da2e0180784895b82ee4b7518184b4,

title = "Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer.",

abstract = "Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.British Journal of Cancer (2008) 99, 459-463. doi:10.1038/sj.bjc.6604474 www.bjcancer.com Published online 22 July 2008.",

author = "M Seenath and DL Roberts and C Cawthorne and M Saunders and G Armstrong and S O'Dwyer and IJ Stratford and C Dive and Andrew Renehan",

year = "2008",

language = "English",

volume = "99( 3)",

journal = "Br J Cancer",

issn = "1532-1827",

publisher = "Springer Nature",

}

TY - JOUR

T1 - Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer.

AU - Seenath, M

AU - Roberts, DL

AU - Cawthorne, C

AU - Saunders, M

AU - Armstrong, G

AU - O'Dwyer, S

AU - Stratford, IJ

AU - Dive, C

AU - Renehan, Andrew

PY - 2008

Y1 - 2008

N2 - Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.British Journal of Cancer (2008) 99, 459-463. doi:10.1038/sj.bjc.6604474 www.bjcancer.com Published online 22 July 2008.

AB - Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain.British Journal of Cancer (2008) 99, 459-463. doi:10.1038/sj.bjc.6604474 www.bjcancer.com Published online 22 July 2008.

M3 - Article

SN - 1532-1827

VL - 99( 3)

JO - Br J Cancer

JF - Br J Cancer

ER -

Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein Bid in ex vivo colorectal cancer.

Abstract

UN SDGs

Fingerprint

Cite this