Recombinant expression systems for the production of collagen

N. J. Bulleid, D. C A John, K. E. Kadler

    Research output: Contribution to journalArticlepeer-review


    The ability of triple-helical collagen molecules to assemble into supramolecular structures forms the basis of commercial uses of collagen in the food industry and in medical applications such as cosmetic surgery and tissue repair. We have used cDNA techniques to engineer novel collagens with potentially enhanced biological properties; however, expression of fully functional novel molecules is difficult due to the complex nature of procollagen biosynthesis. This article outlines the application of various expression systems to procollagen production and details the use of the mammary gland as a suitable bioreactor for the synthesis of significant amounts of novel procollagens from cDNA constructs.
    Original languageEnglish
    Pages (from-to)350-353
    Number of pages3
    JournalBiochemical Society Transactions
    Issue number4
    Publication statusPublished - 2000


    • Procollagen
    • Recombinant protein
    • Tissue engineering
    • Transgenic animals


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