Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel

James L Januzzi, Simon A Mahler, Robert H Christenson, Jennifer Rymer, L Kristin Newby, Richard Body, David A Morrow, Allan S Jaffe

Research output: Contribution to journalReview articlepeer-review


High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding greater clinical sensitivity for myocardial injury and allowing accurate recognition of small changes in troponin concentration (rise or fall) within a short time frame. Although much of the knowledge regarding troponin biology that was applicable with older troponin assays still holds true, considerable education regarding the differences between conventional cTn and hs-cTn is needed before medical systems convert to the newer methods. This includes a basic understanding of how hs-cTn testing differs from conventional cTn testing and how it is best deployed in different settings, such as the emergency department and inpatient services. This Expert Panel will review important concepts for institutional transition to hs-cTn methodology, providing recommendations useful for education before implementation.

Original languageEnglish
Pages (from-to)1059-1077
Number of pages19
JournalJournal of the American College of Cardiology
Issue number9
Publication statusPublished - 12 Mar 2019


  • Biomarkers/blood
  • Clinical Decision-Making/methods
  • Emergency Service, Hospital
  • Humans
  • Myocardial Infarction/blood
  • Practice Guidelines as Topic
  • Troponin/blood


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