Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant

Ying Taur, Katharine Coyte, Schluter, Robilotti, Figueroa, Gjonbalaj, Littmann, Ling, Miller, Gyaltshen, Fontana, Morjaria, Gyurkocza, Perales, Castro-Malaspina, Tamari, Ponce, Koehne, Barker, JakubowskiPapadopoulos, Dahi, Sauter, Shaffer, Young, Peled, Meagher, Jenq, Van Den Brink, Giralt, Pamer, Xavier

Research output: Contribution to journalArticlepeer-review


Antibiotic treatment can deplete the commensal bacteria of a patient’s gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but significantly disrupts intestinal microbiota diversity, leading to loss of many beneficial microbes. Although gut microbiota diversity loss during allo-HSCT is associated with increased mortality, approaches to reestablish depleted commensal bacteria have yet to be developed. We have initiated a randomized, controlled clinical trial of autologous fecal microbiota transplantation (auto-FMT) versus no intervention and have analyzed the intestinal microbiota profiles of 25 allo-HSCT patients (14 who received auto-FMT treatment and 11 control patients who did not). Changes in gut microbiota diversity and composition revealed that the auto-FMT intervention boosted microbial diversity and reestablished the intestinal microbiota composition that the patient had before antibiotic treatment and allo-HSCT. These results demonstrate the potential for fecal sample banking and posttreatment remediation of a patient’s gut microbiota after microbiota-depleting antibiotic treatment during allo-HSCT.
Original languageEnglish
Article numbereaap9489
JournalScience Translational Medicine
Issue number460
Publication statusPublished - 26 Sept 2018


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