Abstract
{redD} and {actII-ORF4}, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD).} Disruption of {hrdD} had no effect on antibiotic production, indicating that {redD} and {actII-ORF4} are transcribed in vivo by at least one other {RNA} polymerase holoenzyme. These data provide the first experimental evidence that {HrdD} can function as a ?? factor.
Original language | English |
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Pages (from-to) | 3402-3405 |
Number of pages | 4 |
Journal | Journal of Bacteriology |
Volume | 178 |
Issue number | 11 |
Publication status | Published - 1996 |