redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD)

T Fujii; H C Gramajo; E Takano; M J Bibb

redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD)

T Fujii, H C Gramajo, E Takano, M J Bibb

Research output: Contribution to journal › Article › peer-review

Abstract

{redD} and {actII-ORF4}, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD).} Disruption of {hrdD} had no effect on antibiotic production, indicating that {redD} and {actII-ORF4} are transcribed in vivo by at least one other {RNA} polymerase holoenzyme. These data provide the first experimental evidence that {HrdD} can function as a ?? factor.

Original language	English
Pages (from-to)	3402-3405
Number of pages	4
Journal	Journal of Bacteriology
Volume	178
Issue number	11
Publication status	Published - 1996

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@article{bd8dad9c2d474c5495074f65d9082ef1,

title = "redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD)",

abstract = "{redD} and {actII-ORF4}, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD).} Disruption of {hrdD} had no effect on antibiotic production, indicating that {redD} and {actII-ORF4} are transcribed in vivo by at least one other {RNA} polymerase holoenzyme. These data provide the first experimental evidence that {HrdD} can function as a ?? factor.",

author = "T Fujii and Gramajo, {H C} and E Takano and Bibb, {M J}",

year = "1996",

language = "English",

volume = "178",

pages = "3402--3405",

journal = "Journal of Bacteriology",

issn = "1098-5530",

publisher = "American Society for Microbiology",

number = "11",

}

redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD). / Fujii, T; Gramajo, H C; Takano, E et al.
In: Journal of Bacteriology, Vol. 178, No. 11, 1996, p. 3402-3405.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD)

AU - Fujii, T

AU - Gramajo, H C

AU - Takano, E

AU - Bibb, M J

PY - 1996

Y1 - 1996

N2 - {redD} and {actII-ORF4}, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD).} Disruption of {hrdD} had no effect on antibiotic production, indicating that {redD} and {actII-ORF4} are transcribed in vivo by at least one other {RNA} polymerase holoenzyme. These data provide the first experimental evidence that {HrdD} can function as a ?? factor.

AB - {redD} and {actII-ORF4}, regulatory genes required for synthesis of the antibiotics undecylprodigiosin and actinorhodin by Streptomyces coelicolor A3(2), were transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD).} Disruption of {hrdD} had no effect on antibiotic production, indicating that {redD} and {actII-ORF4} are transcribed in vivo by at least one other {RNA} polymerase holoenzyme. These data provide the first experimental evidence that {HrdD} can function as a ?? factor.

M3 - Article

SN - 1098-5530

VL - 178

SP - 3402

EP - 3405

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 11

ER -

redD} and {actII-ORF4}, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an {RNA} polymerase holoenzyme containing {??(hrdD)

Abstract

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