Reduced D-[3H]aspartate binding in Down's syndrome brains

David Simpson; P Slater; A J Cross; D M Mann; M.C. Royston; J F Deakin; Gavin P. Reynolds

Reduced D-[3H]aspartate binding in Down's syndrome brains

David Simpson, P Slater, A J Cross, D M Mann, M.C. Royston, J F Deakin, Gavin P. Reynolds

Research output: Contribution to journal › Article › peer-review

Abstract

The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.

Original language	English
Pages (from-to)	273-278
Number of pages	6
Journal	Brain research
Volume	484
Issue number	1-2
Publication status	Published - 10 Apr 1989

Keywords

Aged
Aspartic Acid
Brain
Child
Down Syndrome
Humans
Middle Aged
Phencyclidine
Receptors, Glutamate
Receptors, Neurotransmitter
Journal Article
Research Support, Non-U.S. Gov't

Cite this

@article{9144cca92bc440a6b8146e986d7557a1,

title = "Reduced D-[3H]aspartate binding in Down's syndrome brains",

abstract = "The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.",

keywords = "Aged, Aspartic Acid, Brain, Child, Down Syndrome, Humans, Middle Aged, Phencyclidine, Receptors, Glutamate, Receptors, Neurotransmitter, Journal Article, Research Support, Non-U.S. Gov't",

author = "David Simpson and P Slater and Cross, {A J} and Mann, {D M} and M.C. Royston and Deakin, {J F} and Reynolds, {Gavin P.}",

year = "1989",

month = apr,

day = "10",

language = "English",

volume = "484",

pages = "273--278",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier BV",

number = "1-2",

}

TY - JOUR

T1 - Reduced D-[3H]aspartate binding in Down's syndrome brains

AU - Simpson, David

AU - Slater, P

AU - Cross, A J

AU - Mann, D M

AU - Royston, M.C.

AU - Deakin, J F

AU - Reynolds, Gavin P.

PY - 1989/4/10

Y1 - 1989/4/10

N2 - The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.

AB - The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.

KW - Aged

KW - Aspartic Acid

KW - Brain

KW - Child

KW - Down Syndrome

KW - Humans

KW - Middle Aged

KW - Phencyclidine

KW - Receptors, Glutamate

KW - Receptors, Neurotransmitter

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 2540884

SN - 0006-8993

VL - 484

SP - 273

EP - 278

JO - Brain research

JF - Brain research

IS - 1-2

ER -

Reduced D-[3H]aspartate binding in Down's syndrome brains

Abstract

Keywords

Fingerprint

Cite this