Reduced D-[3H]aspartate binding in Down's syndrome brains

David Simpson, P Slater, A J Cross, D M Mann, M.C. Royston, J F Deakin, Gavin P. Reynolds

Research output: Contribution to journalArticlepeer-review


The binding of D-[3H]aspartate to glutamate uptake sites was measured in post-mortem brains from subjects with Down's syndrome (DS) and age-matched controls. DS brains had substantially reduced D-[3H]aspartate binding in the frontal and temporal cortex, hippocampus and caudate nucleus. There was no correlation between the numbers of Alzheimer-like plaques and tangles or clinically-assessed dementia and D-[3H]aspartate binding in DS brains. The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine ([3H]TCP) to postsynaptic N-methyl-D-aspartate sites was normal in DS brains. This study suggests that the reduction in glutamate uptake sites in DS is more substantial and widespread than in Alzheimer's disease.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalBrain research
Issue number1-2
Publication statusPublished - 10 Apr 1989


  • Aged
  • Aspartic Acid
  • Brain
  • Child
  • Down Syndrome
  • Humans
  • Middle Aged
  • Phencyclidine
  • Receptors, Glutamate
  • Receptors, Neurotransmitter
  • Journal Article
  • Research Support, Non-U.S. Gov't


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