Reducing the toll of inflammatory lung disease.

Nazia Chaudhuri; Moira K B Whyte; Ian Sabroe

doi:10.1378/chest.06-2869

Reducing the toll of inflammatory lung disease.

Nazia Chaudhuri, Moira K B Whyte, Ian Sabroe

Research output: Contribution to journal › Article › peer-review

Abstract

Toll-like receptors (TLRs) are pivotal in human response to microbial stimuli. Their activation and signaling underpin much of the observed epidemiologic data generated by the hygiene hypothesis, and their contribution to infectious exacerbations of airways disease is likely to be highly important. Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity.

Original language	English
Journal	Chest
Volume	131
Issue number	5
DOIs	https://doi.org/10.1378/chest.06-2869
Publication status	Published - May 2007

Keywords

Inflammation
Lung Disease
TLR
Toll like receptors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1378/chest.06-2869

Cite this

@article{d44d2b1961a144a3a3cb5cb28d6e1788,

title = "Reducing the toll of inflammatory lung disease.",

abstract = "Toll-like receptors (TLRs) are pivotal in human response to microbial stimuli. Their activation and signaling underpin much of the observed epidemiologic data generated by the hygiene hypothesis, and their contribution to infectious exacerbations of airways disease is likely to be highly important. Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity.",

keywords = "Inflammation, Lung Disease, TLR, Toll like receptors",

author = "Nazia Chaudhuri and Whyte, {Moira K B} and Ian Sabroe",

note = "G116/170, Medical Research Council, United Kingdom",

year = "2007",

month = may,

doi = "10.1378/chest.06-2869",

language = "English",

volume = "131",

journal = "Chest",

issn = "1931-3543",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Reducing the toll of inflammatory lung disease.

AU - Chaudhuri, Nazia

AU - Whyte, Moira K B

AU - Sabroe, Ian

N1 - G116/170, Medical Research Council, United Kingdom

PY - 2007/5

Y1 - 2007/5

N2 - Toll-like receptors (TLRs) are pivotal in human response to microbial stimuli. Their activation and signaling underpin much of the observed epidemiologic data generated by the hygiene hypothesis, and their contribution to infectious exacerbations of airways disease is likely to be highly important. Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity.

AB - Toll-like receptors (TLRs) are pivotal in human response to microbial stimuli. Their activation and signaling underpin much of the observed epidemiologic data generated by the hygiene hypothesis, and their contribution to infectious exacerbations of airways disease is likely to be highly important. Our growing knowledge in this field will have a significant impact on the understanding of the pathogenesis of inflammatory diseases, and TLR-based therapies are already in early clinical trials to modify atopic disease severity.

KW - Inflammation

KW - Lung Disease

KW - TLR

KW - Toll like receptors

U2 - 10.1378/chest.06-2869

DO - 10.1378/chest.06-2869

M3 - Article

C2 - 17494804

SN - 1931-3543

VL - 131

JO - Chest

JF - Chest

IS - 5

ER -

Reducing the toll of inflammatory lung disease.

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this