Reductive cyclisations of amidines involving aminal radicals

Huan-ming Huang; Ralph W. Adams; David J. Procter

doi:10.1039/C8CC05178J

Reductive cyclisations of amidines involving aminal radicals

Huan-ming Huang, Ralph W. Adams, David J. Procter

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Abstract

Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.

Original language	English
Pages (from-to)	10160-10163
Journal	Chemical Communications
Volume	54
Issue number	72
Early online date	15 Aug 2018
DOIs	https://doi.org/10.1039/C8CC05178J
Publication status	Published - 2018

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DJP-HH-REV-AminalRad-CC-Aug13Accepted author manuscript, 5.03 MB

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title = "Reductive cyclisations of amidines involving aminal radicals",

abstract = "Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.",

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DO - 10.1039/C8CC05178J

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SP - 10160

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JO - Chemical Communications

JF - Chemical Communications

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Reductive cyclisations of amidines involving aminal radicals

Abstract

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