Regiodivergent copper catalyzed borocyanation of 1,3-dienes

Tao Jia, Qiong He, Rebecca E Ruscoe, Alexander Pulis, David John Procter

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    Abstract

    Copper catalyzed multifunctionalization of unsaturated carbon‐carbon bonds is a powerful tool for the generation of complex molecules. We report a regiodivergent process that allows a switch between 1,4‐borocupration and 4,1‐borocupration of 1,3‐dienes upon a simple change in ligand. The subsequently generated allyl coppers are trapped in an electrophilic cyanation to selectively generate densely functionalized and synthetically versatile 1,2‐ or 4,3‐ borocyanation products.
    Original languageEnglish
    JournalAngewandte Chemie International Edition
    Volume57
    Issue number35
    Early online date10 Jul 2018
    DOIs
    Publication statusPublished - 27 Aug 2018

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