Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications

Oleg V Aslanidi; Rebecca S Dewey; Alexandra R Morgan; Mark Boyett; Henggui Zhang

doi:10.1109/IEMBS.2008.4649110

Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications

Oleg V Aslanidi, Rebecca S Dewey, Alexandra R Morgan, Mark Boyett, Henggui Zhang

Division of Cardiovascular Sciences (L5)

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Abstract

Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, I-10, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.

Original language	English
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings
Place of Publication	United States
Publisher	IEEE
Pages	141-144
Number of pages	4
Volume	2008
ISBN (Print)	1557-170X 978-1-4244-1814-5
DOIs	https://doi.org/10.1109/IEMBS.2008.4649110
Publication status	Published - 2008
Event	30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society - Vancouver, CANADA Duration: 20 Aug 2008 → 24 Aug 2008

Conference

Conference	30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
City	Vancouver, CANADA
Period	20/08/08 → 24/08/08

Keywords

Engineering, Biomedical
Engineering, Electrical & Electronic

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10.1109/IEMBS.2008.4649110

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Aslanidi, O. V., Dewey, R. S., Morgan, A. R., Boyett, M., & Zhang, H. (2008). Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications. In Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings (Vol. 2008, pp. 141-144). IEEE. https://doi.org/10.1109/IEMBS.2008.4649110

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title = "Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications",

abstract = "Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, I-10, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.",

keywords = "Engineering, Biomedical, Engineering, Electrical & Electronic",

author = "Aslanidi, {Oleg V} and Dewey, {Rebecca S} and Morgan, {Alexandra R} and Mark Boyett and Henggui Zhang",

note = "Devicix, Green Coll Natl Inst Hlth Nibib N. S. F. Plexon Inc U. B. C. Engn Aslanidi, Oleg V. Dewey, Rebecca S. Morgan, Alexandra R. Boyett, Mark R. Zhang, Henggui 20 NEW YORK BIS22; 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society ; Conference date: 20-08-2008 Through 24-08-2008",

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doi = "10.1109/IEMBS.2008.4649110",

language = "English",

isbn = "1557-170X 978-1-4244-1814-5",

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booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings",

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Aslanidi, OV, Dewey, RS, Morgan, AR, Boyett, M & Zhang, H 2008, Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications. in Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings. vol. 2008, IEEE, United States, pp. 141-144, 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Vancouver, CANADA, 20/08/08. https://doi.org/10.1109/IEMBS.2008.4649110

Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications. / Aslanidi, Oleg V; Dewey, Rebecca S; Morgan, Alexandra R et al.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings. Vol. 2008 United States: IEEE, 2008. p. 141-144.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications

AU - Aslanidi, Oleg V

AU - Dewey, Rebecca S

AU - Morgan, Alexandra R

AU - Boyett, Mark

AU - Zhang, Henggui

N1 - Devicix, Green Coll Natl Inst Hlth Nibib N. S. F. Plexon Inc U. B. C. Engn Aslanidi, Oleg V. Dewey, Rebecca S. Morgan, Alexandra R. Boyett, Mark R. Zhang, Henggui 20 NEW YORK BIS22

PY - 2008

Y1 - 2008

N2 - Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, I-10, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.

AB - Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, I-10, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.

KW - Engineering, Biomedical

KW - Engineering, Electrical & Electronic

U2 - 10.1109/IEMBS.2008.4649110

DO - 10.1109/IEMBS.2008.4649110

M3 - Conference contribution

C2 - 19162613

SN - 1557-170X 978-1-4244-1814-5

VL - 2008

SP - 141

EP - 144

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society Proceedings

PB - IEEE

CY - United States

T2 - 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society

Y2 - 20 August 2008 through 24 August 2008

ER -

Regional Differences in Rabbit Atrial Action Potential Properties: Mechanisms, Consequences and Pharmacological Implications

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Conference

Keywords

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