Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

Maiko Kawasaki; Katsushige Kawasaki; Shelly Oommen; James Blackburn; Momoko Watanabe; Takahiro Nagai; Atsushi Kitamura; Takeyasu Maeda; Bigang Liu; Ruth Schmidt-Ullrich; Taishin Akiyama; Jun-Ichiro Inoue; Nigel Hammond; Paul T Sharpe; Atsushi Ohazama

doi:10.1002/dvdy.24427

Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

Maiko Kawasaki, Katsushige Kawasaki, Shelly Oommen, James Blackburn, Momoko Watanabe, Takahiro Nagai, Atsushi Kitamura, Takeyasu Maeda, Bigang Liu, Ruth Schmidt-Ullrich, Taishin Akiyama, Jun-Ichiro Inoue, Nigel Hammond, Paul T Sharpe, Atsushi Ohazama

Division of Dentistry (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood.

RESULTS: We found Ikkα and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikkα and Irf6 in filiform papillae development. Ikkα and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue.

CONCLUSIONS: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkα and Irf6. Developmental Dynamics 245:937-946, 2016. © 2016 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	937-946
Number of pages	10
Journal	Developmental dynamics : an official publication of the American Association of Anatomists
Volume	245
Issue number	9
Early online date	15 Jun 2016
DOIs	https://doi.org/10.1002/dvdy.24427
Publication status	Published - Sept 2016

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Kawasaki, M., Kawasaki, K., Oommen, S., Blackburn, J., Watanabe, M., Nagai, T., Kitamura, A., Maeda, T., Liu, B., Schmidt-Ullrich, R., Akiyama, T., Inoue, J.-I., Hammond, N., Sharpe, P. T., & Ohazama, A. (2016). Regional regulation of Filiform tongue papillae development by Ikkα/Irf6. Developmental dynamics : an official publication of the American Association of Anatomists, 245(9), 937-946. https://doi.org/10.1002/dvdy.24427

@article{a97ddf3ccf6844bcb024d69d87c2f2d3,

title = "Regional regulation of Filiform tongue papillae development by Ikkα/Irf6",

abstract = "BACKGROUND: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood.RESULTS: We found Ikkα and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikkα and Irf6 in filiform papillae development. Ikkα and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue.CONCLUSIONS: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkα and Irf6. Developmental Dynamics 245:937-946, 2016. {\textcopyright} 2016 Wiley Periodicals, Inc.",

author = "Maiko Kawasaki and Katsushige Kawasaki and Shelly Oommen and James Blackburn and Momoko Watanabe and Takahiro Nagai and Atsushi Kitamura and Takeyasu Maeda and Bigang Liu and Ruth Schmidt-Ullrich and Taishin Akiyama and Jun-Ichiro Inoue and Nigel Hammond and Sharpe, {Paul T} and Atsushi Ohazama",

note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2016",

month = sep,

doi = "10.1002/dvdy.24427",

language = "English",

volume = "245",

pages = "937--946",

journal = "Developmental dynamics : an official publication of the American Association of Anatomists",

issn = "1058-8388",

publisher = "John Wiley & Sons Ltd",

number = "9",

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Kawasaki, M, Kawasaki, K, Oommen, S, Blackburn, J, Watanabe, M, Nagai, T, Kitamura, A, Maeda, T, Liu, B, Schmidt-Ullrich, R, Akiyama, T, Inoue, J-I, Hammond, N, Sharpe, PT & Ohazama, A 2016, 'Regional regulation of Filiform tongue papillae development by Ikkα/Irf6', Developmental dynamics : an official publication of the American Association of Anatomists, vol. 245, no. 9, pp. 937-946. https://doi.org/10.1002/dvdy.24427

TY - JOUR

T1 - Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

AU - Kawasaki, Maiko

AU - Kawasaki, Katsushige

AU - Oommen, Shelly

AU - Blackburn, James

AU - Watanabe, Momoko

AU - Nagai, Takahiro

AU - Kitamura, Atsushi

AU - Maeda, Takeyasu

AU - Liu, Bigang

AU - Schmidt-Ullrich, Ruth

AU - Akiyama, Taishin

AU - Inoue, Jun-Ichiro

AU - Hammond, Nigel

AU - Sharpe, Paul T

AU - Ohazama, Atsushi

PY - 2016/9

Y1 - 2016/9

N2 - BACKGROUND: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood.RESULTS: We found Ikkα and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikkα and Irf6 in filiform papillae development. Ikkα and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue.CONCLUSIONS: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkα and Irf6. Developmental Dynamics 245:937-946, 2016. © 2016 Wiley Periodicals, Inc.

AB - BACKGROUND: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood.RESULTS: We found Ikkα and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikkα and Irf6 in filiform papillae development. Ikkα and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue.CONCLUSIONS: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkα and Irf6. Developmental Dynamics 245:937-946, 2016. © 2016 Wiley Periodicals, Inc.

U2 - 10.1002/dvdy.24427

DO - 10.1002/dvdy.24427

M3 - Article

C2 - 27302476

SN - 1058-8388

VL - 245

SP - 937

EP - 946

JO - Developmental dynamics : an official publication of the American Association of Anatomists

JF - Developmental dynamics : an official publication of the American Association of Anatomists

IS - 9

ER -

Regional regulation of Filiform tongue papillae development by Ikkα/Irf6

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