Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels

Mark T. Nelson; Joseph E. Brayden

doi:10.1007/BF00877627

Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels

Research output: Contribution to journal › Article › peer-review

Abstract

Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization, play a fundamental role in regulating the degree of intravascular pressure-induced, myogenic tone. We found that blockers of KCa channels, charybdotoxin (CTX,

Original language	English
Pages (from-to)	605-610
Number of pages	5
Journal	Cardiovascular Drugs and Therapy
Volume	7
Issue number	3
DOIs	https://doi.org/10.1007/BF00877627
Publication status	Published - Aug 1993

Keywords

arteries
ATP-sensitive potassium channels
Ca2+-activated potassium channels
K+ channel openers
membrane potential
myogenic tone
sulfonylureas
vasodilation

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10.1007/BF00877627

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title = "Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels",

abstract = "Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization, play a fundamental role in regulating the degree of intravascular pressure-induced, myogenic tone. We found that blockers of KCa channels, charybdotoxin (CTX,",

keywords = "arteries, ATP-sensitive potassium channels, Ca2+-activated potassium channels, K+ channel openers, membrane potential, myogenic tone, sulfonylureas, vasodilation",

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AU - Brayden, Joseph E.

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N2 - Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization, play a fundamental role in regulating the degree of intravascular pressure-induced, myogenic tone. We found that blockers of KCa channels, charybdotoxin (CTX,

AB - Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization, play a fundamental role in regulating the degree of intravascular pressure-induced, myogenic tone. We found that blockers of KCa channels, charybdotoxin (CTX,

KW - arteries

KW - ATP-sensitive potassium channels

KW - Ca2+-activated potassium channels

KW - K+ channel openers

KW - membrane potential

KW - myogenic tone

KW - sulfonylureas

KW - vasodilation

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DO - 10.1007/BF00877627

M3 - Article

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EP - 610

JO - Cardiovascular Drugs and Therapy

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IS - 3

ER -

Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels

Abstract

Keywords

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