Regulation of Ca(2+) transient by PP2A in normal and failing heart.

M Lei, X Wang, Y Ke, RJ. Solaro

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.
    Original languageEnglish
    JournalFrontiers in Physics
    Volume6
    Issue number13
    DOIs
    Publication statusPublished - Jan 2015

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