Regulation of Ca(2+) transient by PP2A in normal and failing heart.

M Lei, X Wang, Y Ke, RJ. Solaro

    Research output: Contribution to journalArticlepeer-review


    Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.
    Original languageEnglish
    JournalFrontiers in Physics
    Issue number13
    Publication statusPublished - Jan 2015


    Dive into the research topics of 'Regulation of Ca(2+) transient by PP2A in normal and failing heart.'. Together they form a unique fingerprint.

    Cite this