TY - JOUR
T1 - Regulation of Ca(2+) transient by PP2A in normal and failing heart.
AU - Lei, M
AU - Wang, X
AU - Ke, Y
AU - Solaro, RJ.
PY - 2015/1
Y1 - 2015/1
N2 - Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.
AB - Calcium transient in cardiomyocytes is regulated by multiple protein kinases and phosphatases. PP2A is a major protein phosphatase in the heart modulating Ca(2+) handling through an array of ion channels, antiporters and pumps, etc. The assembly, localization/translocation, and substrate specificity of PP2A are controlled by different post-translational mechanisms, which in turn are linked to the activities of upstream signaling molecules. Abnormal PP2A expression and activities are associated with defective response to β-adrenergic stimulation and are indication and causal factors in arrhythmia and heart failure.
U2 - 10.3389/fphys.2015.00013
DO - 10.3389/fphys.2015.00013
M3 - Article
VL - 6
JO - Frontiers in Physics
JF - Frontiers in Physics
IS - 13
ER -
