Abstract
Nineteen enzymes showing highest activity in liver were examined in human and rodent tissues and cultured cells using starch-gel electrophoresis. The rat hepatoma line Faza 967 strongly expressed 13 of these enzymes. A series of somatic cell hybrids, constructed between Faza and cells of non-hepatic origin derived from man or from Chinese hamster, were examined for expression of these enzymes. Some of the human/rat hybrids continued to produce rat liver-specific enzymes, and the human forms of the enzymes glutamate-pyruvate transaminase, α-glycerophosphate dehydrogenase alcohol dehydrogenase and pyruvate kinase L were reexpressed in a few cases.
| Original language | English |
|---|---|
| Pages (from-to) | 341-356 |
| Number of pages | 15 |
| Journal | Annals of Human Genetics |
| Volume | 45 |
| Issue number | 4 |
| Publication status | Published - 1981 |