Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2α

Andrew Wilcox; Katherine A. Hinchliffe

doi:10.1016/j.febslet.2008.03.022

Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2α

Research output: Contribution to journal › Article › peer-review

Abstract

Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. © 2008 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	1391-1394
Number of pages	3
Journal	FEBS Letters
Volume	582
Issue number	9
DOIs	https://doi.org/10.1016/j.febslet.2008.03.022
Publication status	Published - 16 Apr 2008

Keywords

Phosphoinositide
PtdIns5P
RNA interference
Tyrosine kinase

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10.1016/j.febslet.2008.03.022

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title = "Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2α",

abstract = "Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. {\textcopyright} 2008 Federation of European Biochemical Societies.",

keywords = "Phosphoinositide, PtdIns5P, RNA interference, Tyrosine kinase",

author = "Andrew Wilcox and Hinchliffe, {Katherine A.}",

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doi = "10.1016/j.febslet.2008.03.022",

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T1 - Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2α

AU - Wilcox, Andrew

AU - Hinchliffe, Katherine A.

PY - 2008/4/16

Y1 - 2008/4/16

N2 - Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. © 2008 Federation of European Biochemical Societies.

AB - Cellular levels of the phosphoinositide PtdIns5P are regulated by agonist stimulation, but the mechanisms controlling turnover of this lipid, and the subcellular location of the regulated PtdIns5P pool(s), remain poorly understood. Here we show that enhanced tyrosine phosphorylation robustly increases cellular PtdIns5P levels. Moreover, unlike PtdIns5P production enhanced by cell stress, we show that this pool of PtdIns5P is specifically regulated by the inositol lipid kinase PIP4K2a. © 2008 Federation of European Biochemical Societies.

KW - Phosphoinositide

KW - PtdIns5P

KW - RNA interference

KW - Tyrosine kinase

U2 - 10.1016/j.febslet.2008.03.022

DO - 10.1016/j.febslet.2008.03.022

M3 - Article

VL - 582

SP - 1391

EP - 1394

JO - FEBS Letters

JF - FEBS Letters

IS - 9

ER -

Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2α

Abstract

Keywords

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