Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch

S. Sheldon; P. S. Hasleton; N. A. Yonan; A. N. Rhaman; A. K. Deiraniya; C. S. Campbell; N. H. Brooks; P. A. Dyer

Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch

S. Sheldon, P. S. Hasleton, N. A. Yonan, A. N. Rhaman, A. K. Deiraniya, C. S. Campbell, N. H. Brooks, P. A. Dyer

Research output: Contribution to journal › Article › peer-review

Abstract

It is well established that incompatible HLA antigens presented by donor tissue readily evoke an immune response. Prospective HLA matching policies, widespread in European kidney transplant centers have reduced the level of HLA mismatching and have significantly improved graft survival. The influence of HLA incompatibility in heart transplantation remains controversial, and prospective HLA matching is seldom achieved. We examined the role of HLA antigen mismatching on transplant rejection by analyzing 2569 endomyocardial biopsies (EMB) from 157 consecutive orthotopic heart transplants performed from April 1987 to August 1993 in our own center. Biopsies were graded according to the accepted International Classification, with grade 2 and higher indicating rejection. Among 91 patients who received a 2 HLA-DR mismatch transplant 34% of 1624 biopsies analyzed were graded as ≥2. This frequency fell to 29% of 797 biopsies for 53 patients with a one-HLA-DR mismatch and to 18% of 148 biopsies for 13 patients in the zero-HLA-DR- mismatch group (P

Original language	English
Pages (from-to)	719-722
Number of pages	3
Journal	Transplantation
Volume	58
Issue number	6
Publication status	Published - 1994

Keywords

Adolescent
Adult
Child
immunology: Endocardium
diagnosis: Graft Rejection
Graft Survival
analysis: HLA-DR Antigens
immunology: Heart Transplantation
Histocompatibility Testing
Humans
Middle Aged
immunology: Myocardium

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title = "Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch",

abstract = "It is well established that incompatible HLA antigens presented by donor tissue readily evoke an immune response. Prospective HLA matching policies, widespread in European kidney transplant centers have reduced the level of HLA mismatching and have significantly improved graft survival. The influence of HLA incompatibility in heart transplantation remains controversial, and prospective HLA matching is seldom achieved. We examined the role of HLA antigen mismatching on transplant rejection by analyzing 2569 endomyocardial biopsies (EMB) from 157 consecutive orthotopic heart transplants performed from April 1987 to August 1993 in our own center. Biopsies were graded according to the accepted International Classification, with grade 2 and higher indicating rejection. Among 91 patients who received a 2 HLA-DR mismatch transplant 34% of 1624 biopsies analyzed were graded as ≥2. This frequency fell to 29% of 797 biopsies for 53 patients with a one-HLA-DR mismatch and to 18% of 148 biopsies for 13 patients in the zero-HLA-DR- mismatch group (P",

keywords = "Adolescent, Adult, Child, immunology: Endocardium, diagnosis: Graft Rejection, Graft Survival, analysis: HLA-DR Antigens, immunology: Heart Transplantation, Histocompatibility Testing, Humans, Middle Aged, immunology: Myocardium",

author = "S. Sheldon and Hasleton, {P. S.} and Yonan, {N. A.} and Rhaman, {A. N.} and Deiraniya, {A. K.} and Campbell, {C. S.} and Brooks, {N. H.} and Dyer, {P. A.}",

year = "1994",

language = "English",

volume = "58",

pages = "719--722",

journal = "Transplantation",

issn = "1534-6080",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch

AU - Sheldon, S.

AU - Hasleton, P. S.

AU - Yonan, N. A.

AU - Rhaman, A. N.

AU - Deiraniya, A. K.

AU - Campbell, C. S.

AU - Brooks, N. H.

AU - Dyer, P. A.

PY - 1994

Y1 - 1994

N2 - It is well established that incompatible HLA antigens presented by donor tissue readily evoke an immune response. Prospective HLA matching policies, widespread in European kidney transplant centers have reduced the level of HLA mismatching and have significantly improved graft survival. The influence of HLA incompatibility in heart transplantation remains controversial, and prospective HLA matching is seldom achieved. We examined the role of HLA antigen mismatching on transplant rejection by analyzing 2569 endomyocardial biopsies (EMB) from 157 consecutive orthotopic heart transplants performed from April 1987 to August 1993 in our own center. Biopsies were graded according to the accepted International Classification, with grade 2 and higher indicating rejection. Among 91 patients who received a 2 HLA-DR mismatch transplant 34% of 1624 biopsies analyzed were graded as ≥2. This frequency fell to 29% of 797 biopsies for 53 patients with a one-HLA-DR mismatch and to 18% of 148 biopsies for 13 patients in the zero-HLA-DR- mismatch group (P

AB - It is well established that incompatible HLA antigens presented by donor tissue readily evoke an immune response. Prospective HLA matching policies, widespread in European kidney transplant centers have reduced the level of HLA mismatching and have significantly improved graft survival. The influence of HLA incompatibility in heart transplantation remains controversial, and prospective HLA matching is seldom achieved. We examined the role of HLA antigen mismatching on transplant rejection by analyzing 2569 endomyocardial biopsies (EMB) from 157 consecutive orthotopic heart transplants performed from April 1987 to August 1993 in our own center. Biopsies were graded according to the accepted International Classification, with grade 2 and higher indicating rejection. Among 91 patients who received a 2 HLA-DR mismatch transplant 34% of 1624 biopsies analyzed were graded as ≥2. This frequency fell to 29% of 797 biopsies for 53 patients with a one-HLA-DR mismatch and to 18% of 148 biopsies for 13 patients in the zero-HLA-DR- mismatch group (P

KW - Adolescent

KW - Adult

KW - Child

KW - immunology: Endocardium

KW - diagnosis: Graft Rejection

KW - Graft Survival

KW - analysis: HLA-DR Antigens

KW - immunology: Heart Transplantation

KW - Histocompatibility Testing

KW - Humans

KW - Middle Aged

KW - immunology: Myocardium

M3 - Article

SN - 1534-6080

VL - 58

SP - 719

EP - 722

JO - Transplantation

JF - Transplantation

IS - 6

ER -

Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch

Abstract

Keywords

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