Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 302-310 |
| Number of pages | 9 |
| Journal | Acta Physiologica Hungarica |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- airway inflammation
- asthma
- asthma control
- fractional exhaled nitric oxide
- lung function
- pregnancy
- T cell profiles
- nitric oxide
- adult
- allergic asthma
- article
- circulating T lymphocyte
- clinical article
- correlation analysis
- female
- flow cytometry
- human
- human cell
- immunological tolerance
- natural killer T cell
- pregnancy disorder
- regulatory T lymphocyte
- respiratory tract inflammation
- second trimester pregnancy
- T lymphocyte
- Th1 cell
- Th2 cell
- third trimester pregnancy
- Adult
- Asthma
- Biological Markers
- Breath Tests
- Cross-Sectional Studies
- Eosinophils
- Female
- Humans
- Killer Cells, Natural
- Lung
- Nitric Oxide
- Pneumonia
- Pregnancy
- Pregnancy Complications
- T-Lymphocyte Subsets
- T-Lymphocytes, Regulatory
- Th1 Cells
- Th2 Cells
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In: Acta Physiologica Hungarica, Vol. 99, No. 3, 2012, p. 302-310.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Relation of circulating T cell profiles to airway inflammation and asthma control in asthmatic pregnancy
AU - Eszes, N.
AU - Bohács, A.
AU - Cseh, A.
AU - Toldi, G.
AU - Bikov, A.
AU - Ivancsó, I.
AU - Müller, V.
AU - Horváth, I.
AU - Rigó, J.
AU - Vásárhelyi, B.
AU - Losonczy, G.
AU - Tamási, L.
N1 - Cited By :2 Export Date: 20 February 2019 CODEN: APHDU Correspondence Address: Tamási, L.; Semmelweis University, Department of Pulmonology, Diósárok u. 1/c, H-1125 Budapest, Hungary; email: [email protected] Chemicals/CAS: nitric oxide, 10102-43-9; Biological Markers; Nitric Oxide, 10102-43-9 References: Adamec, R., Walling, S., Burton, P., Long-lasting, selective, anxiogenic effects of feline predator stress in mice (2004) Physiology and Behavior, 83 (3), pp. 401-410. , DOI 10.1016/j.physbeh.2004.08.029, PII S0031938404003671; Bagby, G.J., Sawaya, D.E., Crouch, L.D., Shepherd, R.E., Prior exercise suppresses the plasma tumor necrosis factor response to bacterial lipopolysaccharide (1994) Journal of Applied Physiology, 77 (3), pp. 1542-1547; Bedford, T.G., Tipton, C.M., Wilson, N.C., Maximum oxygen consumption of rats and its changes with various experimental procedures (1979) Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, 47 (6), pp. 1278-1283; Bruunsgaard, H., Galbo, H., Halkjaer-Kristensen, J., Johansen, T.L., MacLean, D.A., Pedersen, B.K., Exercise-induced increase in serum inferleukin-6 in humans is related to muscle damage (1997) Journal of Physiology, 499 (3), pp. 833-841; Brydon, L., Edwards, S., Jia, H., Mohamed-Ali, V., Zachary, I., Martin, J.F., Steptoe, A., Psychological stress activates interleukin-1β gene expression in human mononuclear cells (2005) Brain, Behavior, and Immunity, 19 (6), pp. 540-546. , DOI 10.1016/j.bbi.2004.12.003, PII S0889159105000164; Brydon, L., Edwards, S., Mohamed-Ali, V., Steptoe, A., Socioeconomic status and stress-induced increases in interleukin-6 (2004) Brain, Behavior, and Immunity, 18 (3), pp. 281-290. , DOI 10.1016/j.bbi.2003.09.011, PII S0889159103001673; Chen, J.-X., Zhao, X., Yue, G.-X., Wang, Z.-F., Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A 1-13 (2007) Cellular and Molecular Neurobiology, 27 (1), pp. 1-10. , DOI 10.1007/s10571-006-9110-4; Cohen, M.C., Cohen, S., Cytokine function: A study in biologic diversity (1996) American Journal of Clinical Pathology, 105 (5), pp. 589-598; Dobbin, J.P., Harth, M., McCain, G.A., Martin, R.A., Cousin, K., Cytokine production and lymphocyte transformation during stress (1991) Brain. Behav. Immun., 5, pp. 339-348; Febbraio, M.A., Pedersen, B.K., Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles (2002) FASEB Journal, 16 (11), pp. 1335-1347. , DOI 10.1096/fj.01-0876rev; Goebel, M.U., Mills, P.J., Irwin, M.R., Ziegler, M.G., Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: Differential effects and pathways (2000) Psychosomatic Medicine, 62 (4), pp. 591-598; Haahr, P.M., Pedersen, B.K., Fomsgaard, A., Tvede, N., Diamant, M., Klarlund, K., Halkjaer-Kristensen, J., Bendtzen, K., Effect of physical exercise on in vitro production of interleukin 1, interleukin 6, tumour necrosis factor-alpha, interleukin 2 and interferon-gamma (1991) Int. J. Sports Med., 12, pp. 223-227; Heinz, A., Hermann, D., Smolka, M.N., Rieks, M., Graf, K.-J., Pohlau, D., Kuhn, W., Bauer, M., Effects of acute psychological stress on adhesion molecules, interleukins and sex hormones: Implications for coronary heart disease (2003) Psychopharmacology, 165 (2), pp. 111-117. , DOI 10.1007/s00213-002-1244-6; Hu, J., Ningyi, X., The progression on research of the influence of stress on neuro-endocrine system (2002) J. Hangzhou Teachers College (Natural Science, 5, p. 65; Isobe, H., Okajima, K., Harada, N., Liu, W., Okabe, H., Activated protein C reduces stress-induced gastric mucosal injury in rats by inhibiting the endothelial cell injury (2004) Journal of Thrombosis and Haemostasis, 2 (2), pp. 313-320. , DOI 10.1046/j.1538-7933.2003.00574.x; Iwamoto, J., Takeda, T., Sato, Y., Effect of treadmill exercise on bone mass in female rats (2005) Experimental Animals, 54 (1), pp. 1-6. , http://www.jstage.jst.go.jp/article/expanim/54/1/54_1/_article, DOI 10.1538/expanim.54.1; Kaur, C., Singh, J., Peng, C.M., Ling, E.A., Upregulation of adrenocorticotrophic hormone in the corticotrophs and downregulation of surface receptors and antigens on the macrophages in the adenohypophysis following an exposure to high altitude (2002) Neuroscience Letters, 318 (3), pp. 125-128. , DOI 10.1016/S0304-3940(01)02474-0, PII S0304394001024740; Lee, P.A., Wallin, J.D., Kaplowitz, N., Burkhartsmeier, G.L., Kane, J.P., Lewis, S.B., Endocrine and metabolic alterations with food and water deprivation (1977) Am. J. Clin. Nutr., 30, pp. 1953-1962; Li, Z.G., Danis, V.A., Brooks, P.M., Effect of gonadal steroids on the production of IL-1 and IL-6 blood mononuclear cells in vitro (1993) Clinical and Experimental Rheumatology, 11 (2), pp. 157-162; Luger, A., Deuster, P.A., Kyle, S.B., Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training (1987) New England Journal of Medicine, 316 (21), pp. 1309-1315; Maes, M., Bosmans, E., Meltzer, H.Y., Scharpe, S., Suy, E., Interleukin-1β: A putative mediator of HPA axis hyperactivity in major depression? (1993) American Journal of Psychiatry, 150 (8), pp. 1189-1193; Metz, J.R., Huising, M.O., Leon, K., Verburg-Van Kemenade, B.M.L., Flik, G., Central and peripheral interleukin-1β and interleukin-1 receptor i expression and their role in the acute stress response of common carp, Cyprinus carpio L (2006) Journal of Endocrinology, 191 (1), pp. 25-35. , DOI 10.1677/joe.1.06640; Moynihan, J.A., Callahan, T.A., Kelley, S.P., Campbell, L.M., Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: Dexamethasone and dehydroepiandrosterone suppress interleukin- 2, interleukin-4, and interferon-γ production in vitro (1998) Cellular Immunology, 184 (1), pp. 58-64. , DOI 10.1006/cimm.1998.1259; Nieman, D.C., Exercise, upper respiratory tract infection, and the immune system (1994) Medicine and Science in Sports and Exercise, 26 (2), pp. 128-139; Nukina, H., Sudo, N., Komaki, G., Yu, X.-N., Mine, K., Kubo, C., The restraint stress-induced elevation in plasma interleukin-6 negatively regulates the plasma TNF-α level (1998) NeuroImmunoModulation, 5 (6), pp. 323-327. , DOI 10.1159/000026352; Padovan, C.M., Guimaraes, F.S., Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats (2004) Pharmacology Biochemistry and Behavior, 77 (1), pp. 15-19. , DOI 10.1016/j.pbb.2003.09.015; Polkowska, J., Przekop, F., Immunocytochemical changes in hypothalamic and pituitary hormones after acute and prolonged stressful stimuli in the anestrous ewe (1988) Acta Endocrinol. (Copenh, 118, pp. 269-276; Raastad, T., Bjoro, T., Hallen, J., Hormonal responses to high- and moderate-intensity strength exercise (2000) European Journal of Applied Physiology, 82 (1-2), pp. 121-128; Reyes, T.M., Coe, C.L., Resistance of central nervous system interleukin-6 to glucocorticoid inhibition in monkeys (1998) Am. J. Physiol., 275, pp. R612-618; Rybkin, I.I., Zhou, Y., Volaufova, J., Smagin, G.N., Ryan, D.H., Harris, R.B.S., Effect of restraint stress on food intake and body weight is determined by time of day (1997) American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 273, pp. R1612-R1622; Samson, J., Sheeladevi, R., Ravindran, R., Senthilvelan, M., Stress response in rat brain after different durations of noise exposure (2007) Neuroscience Research, 57 (1), pp. 143-147. , DOI 10.1016/j.neures.2006.09.019, PII S0168010206002562; Smith, J.A., Guidelines, standards, and perspectives in exercise immunology (1995) Med. Sci. Sports Exerc., 27, pp. 497-506; Suzuki, K., Totsuka, M., Nakaji, S., Yamada, M., Kudoh, S., Liu, Q., Sugawara, K., Sato, K., Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage (1999) Journal of Applied Physiology, 87 (4), pp. 1360-1367; Viru, A., Plasma hormones and physical exercise (1992) Int. J. Sports Med., 13, pp. 201-209; Steptoe, A., Willemsen, G., Owen, N., Flower, L., Mohamed-Ali, V., Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels (2001) Clinical Science, 101 (2), pp. 185-192. , DOI 10.1042/CS20010038; Weinstein, R.S., Nicholas, R.W., Manolagas, S.C., Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip (2000) Journal of Clinical Endocrinology and Metabolism, 85 (8), pp. 2907-2912. , DOI 10.1210/jc.85.8.2907; Wittert, G.A., Livesey, J.H., Espiner, E.A., Donald, R.A., Adaptation of the hypothalamopituitary adrenal axis to chronic exercise stress in humans (1996) Medicine and Science in Sports and Exercise, 28 (8), pp. 1015-1019; Xiong, W., Wei, H., Xiang, X., Cao, J., Dong, Z., Wang, Y., Xu, T., Xu, L., The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages (2004) Brain Research, 1005 (1-2), pp. 187-192. , DOI 10.1016/j.brainres.2004.01.051, PII S0006899304001696; Xu, Y., Zhang, B., Zhang, Y., Xue, Y., Xiao, J., Change of plasma cortisol level before and after high intensity training (2000) Clin. J. Medical Officer, 28, pp. 63-64; Yang, X., (1998) Practical Physiology of Exercise, pp. 167-168. , Beijing Sports University Publishers Beijing; Yin, J., Yan, J., The influence of exercise training on rat endocrine-immunological parameters (2006) J. Beijing Sport University, 29, pp. 70-73; Zarkovic, M., Stefanova, E., Ciric, J., Penezic, Z., Kostic, V., Sumarac-Dumanovic, M., MacUt, D., Gligorovic, P.V., Prolonged psychological stress suppresses cortisol secretion (2003) Clinical Endocrinology, 59 (6), pp. 811-816. , DOI 10.1046/j.1365-2265.2003.01925.x; Zeng, W., Zhi, X., Wu, X., Wu, G., Zhang, Y., Yang, X., XueSong: Effects of stress on psychology and serum concentrations of thyroxin, testosterone and cortisol in seamen (2004) Chin. J. Naut. Med. & Hyperbar. Med., 11, pp. 20-22; Zhang, J., Chen, P., Zhang, J., Zhuang, J., Pi, Y., Jie, R., The effects of the psychological stress and training on immunological parameters in different trait anxiety athletes (2000) Chin. J. Sports Med., 19, pp. 177-178; Zhou, D., Kusnecov, A.W., Shurin, M.R., Depaoli, M., Rabin, B.S., Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary- adrenal axis (1993) Endocrinology, 133 (6), pp. 2523-2530. , DOI 10.1210/en.133.6.2523
PY - 2012
Y1 - 2012
N2 - Asthmatic inflammation during pregnancy poses a risk for maternal and fetal morbidities. Circulating T cell immune phenotype is known to correlate with airway inflammation (detectable by fractional concentration of nitric oxide present in exhaled breath (FENO)) in non-pregnant allergic asthmatics. The aim of this study was to assess the relationship of peripheral T cell phenotype to FENO and clinical variables of asthma during pregnancy.We examined 22 pregnant women with allergic asthma in the 2nd/3rd trimester. The prevalence of Th1, Th2, regulatory T (Treg) and natural killer (NK) cell subsets was identified with flow cytometry using cell-specific markers. FENO, Asthma Control Test (ACT) total score and lung function were evaluated.Peripheral blood Th1, Th2, Treg, and NK cell prevalence were not significantly correlated to airway inflammation assessed by FENO in asthmatic pregnant women (all cells p > 0.05; study power > 75%). However, an inverse correlation was detected between Th2 cell prevalence and ACT total scores (p = 0.03) in asthmatic pregnancy.Blunted relationship between T cell profile and airway inflammation may be the result of pregnancy induced immune tolerance in asthmatic pregnancy. On the other hand, increased Th2 response impairs disease control that supports direct relationship between symptoms and cellular mechanisms of asthma during pregnancy. © 2012 Akadémiai Kiadó, Budapest.
AB - Asthmatic inflammation during pregnancy poses a risk for maternal and fetal morbidities. Circulating T cell immune phenotype is known to correlate with airway inflammation (detectable by fractional concentration of nitric oxide present in exhaled breath (FENO)) in non-pregnant allergic asthmatics. The aim of this study was to assess the relationship of peripheral T cell phenotype to FENO and clinical variables of asthma during pregnancy.We examined 22 pregnant women with allergic asthma in the 2nd/3rd trimester. The prevalence of Th1, Th2, regulatory T (Treg) and natural killer (NK) cell subsets was identified with flow cytometry using cell-specific markers. FENO, Asthma Control Test (ACT) total score and lung function were evaluated.Peripheral blood Th1, Th2, Treg, and NK cell prevalence were not significantly correlated to airway inflammation assessed by FENO in asthmatic pregnant women (all cells p > 0.05; study power > 75%). However, an inverse correlation was detected between Th2 cell prevalence and ACT total scores (p = 0.03) in asthmatic pregnancy.Blunted relationship between T cell profile and airway inflammation may be the result of pregnancy induced immune tolerance in asthmatic pregnancy. On the other hand, increased Th2 response impairs disease control that supports direct relationship between symptoms and cellular mechanisms of asthma during pregnancy. © 2012 Akadémiai Kiadó, Budapest.
KW - airway inflammation
KW - asthma
KW - asthma control
KW - fractional exhaled nitric oxide
KW - lung function
KW - pregnancy
KW - T cell profiles
KW - nitric oxide
KW - adult
KW - allergic asthma
KW - article
KW - circulating T lymphocyte
KW - clinical article
KW - correlation analysis
KW - female
KW - flow cytometry
KW - human
KW - human cell
KW - immunological tolerance
KW - natural killer T cell
KW - pregnancy disorder
KW - regulatory T lymphocyte
KW - respiratory tract inflammation
KW - second trimester pregnancy
KW - T lymphocyte
KW - Th1 cell
KW - Th2 cell
KW - third trimester pregnancy
KW - Adult
KW - Asthma
KW - Biological Markers
KW - Breath Tests
KW - Cross-Sectional Studies
KW - Eosinophils
KW - Female
KW - Humans
KW - Killer Cells, Natural
KW - Lung
KW - Nitric Oxide
KW - Pneumonia
KW - Pregnancy
KW - Pregnancy Complications
KW - T-Lymphocyte Subsets
KW - T-Lymphocytes, Regulatory
KW - Th1 Cells
KW - Th2 Cells
U2 - 10.1556/APhysiol.99.2012.3.7
DO - 10.1556/APhysiol.99.2012.3.7
M3 - Article
SN - 0231-424X
VL - 99
SP - 302
EP - 310
JO - Acta Physiologica Hungarica
JF - Acta Physiologica Hungarica
IS - 3
ER -