Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia

Martin Yuille, Alison Condie, Chantelle Hudson, Zsofia Kote-Jarai, Elaine Stone, Rosalind Eeles, Estella Matutes, Daniel Catovsky, Richard Houlston

    Research output: Contribution to journalArticlepeer-review


    Interindividual differences in susceptibility to hematologic malignancies may be mediated in part through polymorphic variability in the bioactivation and detoxification of carcinogens. The glutathione S-transferases (GSTs) have been implicated as susceptibility genes in this context for a number of cancers. The aim of this study was to examine whether polymorphic variation in GSTs confers susceptibility to chronic lymphocytic leukemia (CLL). GSTM1, GSTT1, and GSTP1 genotypes were determined in 138 patients and 280 healthy individuals. The frequency of both GSTM1 and GSTT1 null genotypes and the GSTP1-lle allele was higher in cases than in controls. There was evidence of a trend in increasing risk with the number of putative "high-risk" alleles of the GST family carried (P = .04). The risk of CLL associated with possession of all 3 "high-risk" genotypes was increased 2.8-fold (OR = 2.8, 95% confidence interval: 1.1-6.9). Our findings suggest that heritable GST status may influence the risk of developing CLL. © 2002 by The American Society of Hematology.
    Original languageEnglish
    Pages (from-to)4216-4218
    Number of pages2
    Issue number11
    Publication statusPublished - 1 Jun 2002


    • enzymology
    • Family
    • Female
    • Gene Frequency
    • genetics
    • Genotype
    • Glutathione S-Transferase pi
    • Glutathione Transferase
    • Humans
    • Isoenzymes
    • Leukemia,Lymphocytic,Chronic,B-Cell
    • Male
    • Middle Aged
    • Polymorphism,Genetic


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