TY - JOUR
T1 - Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence
T2 - Their use in the assessment of disordered growth
AU - Hall, C. M.
AU - Gill, M. S.
AU - Foster, P.
AU - Pennells, L.
AU - Tillmann, V.
AU - Jones, J.
AU - Price, D. A.
AU - Clayton, P. E.
PY - 1999
Y1 - 1999
N2 - OBJECTIVE: Serum insulin-like growth factor-I (sIGF-I) measurement as an index of growth hormone status has become a common test in the investigation of disordered growth. IGF-I may also be measured in the urine. The aims of this study were to investigate the correlation between serum and urinary IGF- I in normal children and compare their use in the evaluation of growth disorders. DESIGN: Normal ranges for serum and urinary IGF-I were devised from a cross-sectional study of normal schoolchildren. These were then used to assess the sensitivity and specificity of serum and urinary IGF-I in the diagnosis of childhood GH deficiency. PATIENTS: A cohort of 333 (M = 156, F = 177) healthy schoolchildren aged 5-19 years were recruited and data previously collected from 22 growth hormone deficient (GHD) and 47 short normal (SN) children were compared with those of the normal children. MEASUREMENTS: Height, weight and pubertal status were assessed in all children. Serum IGF-I (sIGF-I) (n = 305) and total amount of urinary IGF-I excreted overnight (TuIGF-I) (n = 205) were measured by RIA using excess IGF- II to block the interference of IGFBPs. RESULTS: Serum IGF-I was log(e) transformed and overall levels (geometric mean ± 1 tolerance factor) were higher in females than males (F: 569 (329, 985)μg/l; M: 398 (227, 696) μg/l). Log(e)IGF-I correlated with age (F: r=+0.76, P
AB - OBJECTIVE: Serum insulin-like growth factor-I (sIGF-I) measurement as an index of growth hormone status has become a common test in the investigation of disordered growth. IGF-I may also be measured in the urine. The aims of this study were to investigate the correlation between serum and urinary IGF- I in normal children and compare their use in the evaluation of growth disorders. DESIGN: Normal ranges for serum and urinary IGF-I were devised from a cross-sectional study of normal schoolchildren. These were then used to assess the sensitivity and specificity of serum and urinary IGF-I in the diagnosis of childhood GH deficiency. PATIENTS: A cohort of 333 (M = 156, F = 177) healthy schoolchildren aged 5-19 years were recruited and data previously collected from 22 growth hormone deficient (GHD) and 47 short normal (SN) children were compared with those of the normal children. MEASUREMENTS: Height, weight and pubertal status were assessed in all children. Serum IGF-I (sIGF-I) (n = 305) and total amount of urinary IGF-I excreted overnight (TuIGF-I) (n = 205) were measured by RIA using excess IGF- II to block the interference of IGFBPs. RESULTS: Serum IGF-I was log(e) transformed and overall levels (geometric mean ± 1 tolerance factor) were higher in females than males (F: 569 (329, 985)μg/l; M: 398 (227, 696) μg/l). Log(e)IGF-I correlated with age (F: r=+0.76, P
UR - http://www.scopus.com/inward/record.url?scp=0032909278&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2265.1999.00699.x
DO - 10.1046/j.1365-2265.1999.00699.x
M3 - Article
C2 - 10468927
AN - SCOPUS:0032909278
SN - 0300-0664
VL - 50
SP - 611
EP - 618
JO - Clin Endocrinol (Oxf)
JF - Clin Endocrinol (Oxf)
IS - 5
ER -