Relationship between serum and urinary insulin-like growth factor-I through childhood and adolescence: Their use in the assessment of disordered growth

C. M. Hall, M. S. Gill, P. Foster, L. Pennells, V. Tillmann, J. Jones, D. A. Price, P. E. Clayton

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    Abstract

    OBJECTIVE: Serum insulin-like growth factor-I (sIGF-I) measurement as an index of growth hormone status has become a common test in the investigation of disordered growth. IGF-I may also be measured in the urine. The aims of this study were to investigate the correlation between serum and urinary IGF- I in normal children and compare their use in the evaluation of growth disorders. DESIGN: Normal ranges for serum and urinary IGF-I were devised from a cross-sectional study of normal schoolchildren. These were then used to assess the sensitivity and specificity of serum and urinary IGF-I in the diagnosis of childhood GH deficiency. PATIENTS: A cohort of 333 (M = 156, F = 177) healthy schoolchildren aged 5-19 years were recruited and data previously collected from 22 growth hormone deficient (GHD) and 47 short normal (SN) children were compared with those of the normal children. MEASUREMENTS: Height, weight and pubertal status were assessed in all children. Serum IGF-I (sIGF-I) (n = 305) and total amount of urinary IGF-I excreted overnight (TuIGF-I) (n = 205) were measured by RIA using excess IGF- II to block the interference of IGFBPs. RESULTS: Serum IGF-I was log(e) transformed and overall levels (geometric mean ± 1 tolerance factor) were higher in females than males (F: 569 (329, 985)μg/l; M: 398 (227, 696) μg/l). Log(e)IGF-I correlated with age (F: r=+0.76, P

    Original languageEnglish
    Pages (from-to)611-618
    Number of pages8
    JournalClin Endocrinol (Oxf)
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - 1999

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