Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease

Igor Yakushev; Alex Gerhard; Matthias J. Mü ller; Markus Lorscheider; Hans Georg Buchholz; Ingrid Schermuly; Carsten Weibrich; Alexander Hammers; Peter Stoeter; Matthias Schreckenberger; Andreas Fellgiebel

doi:10.1007/s00429-011-0302-4

Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease

Igor Yakushev, Alex Gerhard, Matthias J. Mü ller, Markus Lorscheider, Hans Georg Buchholz, Ingrid Schermuly, Carsten Weibrich, Alexander Hammers, Peter Stoeter, Matthias Schreckenberger, Andreas Fellgiebel

Research output: Contribution to journal › Article › peer-review

Abstract

Abnormal microstructural integrity and glucose metabolism of the hippocampus are common in subjects with Alzheimer's disease (AD) that typically manifest as episodic memory impairment. The above-tissue alterations can be captured in vivo using diffusion tensor imaging (DTI) and positron emission tomography with [18F] fluorodeoxyglucose (FDG-PET). Here, we explored relationships between the above neuroimaging and cognitive markers of early AD-specific hippocampal damage. Twenty patients with early AD (MMSE 25.7 ± 1.7) were studied using DTI and FDG-PET. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). In the between-modality correlation analysis, FDG uptake was strongly associated with diffusivity in the left anterior hippocampus only (r = -0.81, p

Original language	English
Pages (from-to)	219-226
Number of pages	7
Journal	Brain Structure and Function
Volume	216
Issue number	3
DOIs	https://doi.org/10.1007/s00429-011-0302-4
Publication status	Published - Sept 2011

Keywords

Dementia
Diffusion tensor imaging
DT.I.
Episodic memory
PE.T.
Positron emission tomography

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Yakushev, I., Gerhard, A., Mü ller, M. J., Lorscheider, M., Buchholz, H. G., Schermuly, I., Weibrich, C., Hammers, A., Stoeter, P., Schreckenberger, M., & Fellgiebel, A. (2011). Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease. Brain Structure and Function, 216(3), 219-226. https://doi.org/10.1007/s00429-011-0302-4

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AU - Yakushev, Igor

AU - Gerhard, Alex

AU - Mü ller, Matthias J.

AU - Lorscheider, Markus

AU - Buchholz, Hans Georg

AU - Schermuly, Ingrid

AU - Weibrich, Carsten

AU - Hammers, Alexander

AU - Stoeter, Peter

AU - Schreckenberger, Matthias

AU - Fellgiebel, Andreas

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AB - Abnormal microstructural integrity and glucose metabolism of the hippocampus are common in subjects with Alzheimer's disease (AD) that typically manifest as episodic memory impairment. The above-tissue alterations can be captured in vivo using diffusion tensor imaging (DTI) and positron emission tomography with [18F] fluorodeoxyglucose (FDG-PET). Here, we explored relationships between the above neuroimaging and cognitive markers of early AD-specific hippocampal damage. Twenty patients with early AD (MMSE 25.7 ± 1.7) were studied using DTI and FDG-PET. Episodic memory performance was assessed using the free delayed verbal recall task (DVR). In the between-modality correlation analysis, FDG uptake was strongly associated with diffusivity in the left anterior hippocampus only (r = -0.81, p

KW - Dementia

KW - Diffusion tensor imaging

KW - DT.I.

KW - Episodic memory

KW - PE.T.

KW - Positron emission tomography

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SP - 219

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JO - Brain Structure and Function

JF - Brain Structure and Function

IS - 3

ER -

Relationships between hippocampal microstructure, metabolism, and function in early Alzheimer's disease

Abstract

Keywords

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