Relationships between perinatal and maternal characteristics and hepatoblastoma: A report from the UKCCS

P. Ansell; C. D. Mitchell; E. Roman; J. Simpson; J. M. Birch; T. O B Eden

doi:10.1016/j.ejca.2004.10.024

Relationships between perinatal and maternal characteristics and hepatoblastoma: A report from the UKCCS

P. Ansell, C. D. Mitchell, E. Roman, J. Simpson, J. M. Birch, T. O B Eden

Research output: Contribution to journal › Article › peer-review

Abstract

Within the context of a national population-based case-control study - the United Kingdom Childhood Cancer Study (UKCCS) - we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR) = 28.64, 95% Confidence Interval (CI) = 6.94-118.21, P <0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR = 52.50, 95% CI = 10.75-257.05, P <0.0001). Three children with hepatoblastoma weighed

Original language	English
Pages (from-to)	741-748
Number of pages	7
Journal	European Journal of Cancer
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.ejca.2004.10.024
Publication status	Published - Mar 2005

Keywords

Congenital anomalies
Hepatoblastoma
Low birthweight
Polyhydramnios
Pre-eclampsia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2004.10.024

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@article{9867eec5027246978475d964f0682d22,

title = "Relationships between perinatal and maternal characteristics and hepatoblastoma: A report from the UKCCS",

abstract = "Within the context of a national population-based case-control study - the United Kingdom Childhood Cancer Study (UKCCS) - we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR) = 28.64, 95% Confidence Interval (CI) = 6.94-118.21, P <0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR = 52.50, 95% CI = 10.75-257.05, P <0.0001). Three children with hepatoblastoma weighed",

keywords = "Congenital anomalies, Hepatoblastoma, Low birthweight, Polyhydramnios, Pre-eclampsia",

author = "P. Ansell and Mitchell, {C. D.} and E. Roman and J. Simpson and Birch, {J. M.} and Eden, {T. O B}",

note = "Ansell, P Mitchell, C D Roman, E Simpson, J Birch, J M Eden, T O B Multicenter Study Research Support, Non-U.S. Gov't England European journal of cancer (Oxford, England : 1990) Eur J Cancer. 2005 Mar;41(5):741-8. Epub 2005 Jan 5.",

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AU - Ansell, P.

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AU - Roman, E.

AU - Simpson, J.

AU - Birch, J. M.

AU - Eden, T. O B

N1 - Ansell, P Mitchell, C D Roman, E Simpson, J Birch, J M Eden, T O B Multicenter Study Research Support, Non-U.S. Gov't England European journal of cancer (Oxford, England : 1990) Eur J Cancer. 2005 Mar;41(5):741-8. Epub 2005 Jan 5.

PY - 2005/3

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N2 - Within the context of a national population-based case-control study - the United Kingdom Childhood Cancer Study (UKCCS) - we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR) = 28.64, 95% Confidence Interval (CI) = 6.94-118.21, P <0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR = 52.50, 95% CI = 10.75-257.05, P <0.0001). Three children with hepatoblastoma weighed

AB - Within the context of a national population-based case-control study - the United Kingdom Childhood Cancer Study (UKCCS) - we aimed to explore relationships between perinatal and maternal factors and childhood hepatic tumours, for participants with data available from medical records. 26/28 children with hepatic tumours (22/24 hepatoblastomas, 4/4 hepatocellular carcinomas (HCC)) and 4753 age- and sex-matched controls were included. Polyhydramnios was associated with 0.9% of control pregnancies and 13.6% of case pregnancies (Odds Ratio (OR) = 28.64, 95% Confidence Interval (CI) = 6.94-118.21, P <0.0001); eclampsia or severe pre-eclampsia complicated the pregnancies of 16.7% of mothers whose children developed hepatoblastoma compared with 0.5% of control pregnancies (OR = 52.50, 95% CI = 10.75-257.05, P <0.0001). Three children with hepatoblastoma weighed

KW - Congenital anomalies

KW - Hepatoblastoma

KW - Low birthweight

KW - Polyhydramnios

KW - Pre-eclampsia

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DO - 10.1016/j.ejca.2004.10.024

M3 - Article

SN - 0959-8049

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JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 5

ER -

Relationships between perinatal and maternal characteristics and hepatoblastoma: A report from the UKCCS

Abstract

Keywords

UN SDGs

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