Relative frequency and morphology of cancers in carriers of germline TP53 mutations

Jillian M. Birch, Robert D. Alston, Richard J Q McNally, D. Gareth R Evans, Anna M. Kelsey, Martin Harris, Osborn B. Eden, Jennifer M. Varley

Research output: Contribution to journalArticlepeer-review

Abstract

The spectrum and frequency of cancers associated with germline TP53 mutations are uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni syndrome, segregating germline TP53 mutations was established. Predicted cancers were estimated by applying age, morphology, site and sex-specific UK cancer statistics to person-years at risk. Observed and predicted cancers were compared and two-sided P-values calculated. Cancer types occurring to excess and showing P-values
Original languageEnglish
Pages (from-to)4621-4628
Number of pages7
JournalOncogene
Volume20
Issue number34
DOIs
Publication statusPublished - 2 Aug 2001

Keywords

  • Cancer frequency
  • Cancer predisposition
  • Germline TP53 mutations

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