Abstract
The effects of agents that elevate either cyclic AMP (the phosphodiesterase (PDE) III inhibitor siguazodan, salbutamol) or cyclic GMP (sodium nitroprusside (SNP)) on the relaxant activity of the PDE IV inhibitor, rolipram, were investigated in carbachol (0.1 μM) precontracted guinea-pig tracheal sheets. Rolipram, siguazodan and SNP caused concentration-related reductions in tone of tissues precontracted with 0.1 μM carbachol (EC50 values 12.5; 2.73 and 0.35 μM respectively). Whilst the concentration-response relationship for the PDE III inhibitor, siguazodan, was monophasic that of the PDE IV inhibitor, rolipram, was biphasic. The relaxant activity of rolipram was markedly enhanced in the presence of 10 μM siguazodan (EC50
| Original language | English |
|---|---|
| Pages (from-to) | 1047-1052 |
| Number of pages | 5 |
| Journal | British Journal of Pharmacology |
| Volume | 111 |
| Issue number | 4 |
| Publication status | Published - 1994 |
Keywords
- cyclic AMP
- cyclic GMP
- guinea-pig trachea
- relaxation
- rolipram
- salbutamol
- siguazodan
- sodium nitroprusside
