Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat

Alsadek H. Bogzil; Nick Ashton

doi:10.1111/j.1749-6632.2008.03797.x

Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat

Alsadek H. Bogzil, Nick Ashton

Research output: Contribution to journal › Article › peer-review

Abstract

Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 μg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat. © 2009 New York Academy of Sciences.

Original language	English
Pages (from-to)	313-316
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1160
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03797.x
Publication status	Published - Apr 2009

Keywords

Chloride
Kidney
Relaxin
RXFP1 receptor
Sodium

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10.1111/j.1749-6632.2008.03797.x

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title = "Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat",

abstract = "Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 μg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat. {\textcopyright} 2009 New York Academy of Sciences.",

keywords = "Chloride, Kidney, Relaxin, RXFP1 receptor, Sodium",

author = "Bogzil, {Alsadek H.} and Nick Ashton",

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doi = "10.1111/j.1749-6632.2008.03797.x",

language = "English",

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journal = "Annals of the New York Academy of Sciences",

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TY - JOUR

T1 - Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat

AU - Bogzil, Alsadek H.

AU - Ashton, Nick

PY - 2009/4

Y1 - 2009/4

N2 - Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 μg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat. © 2009 New York Academy of Sciences.

AB - Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 μg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat. © 2009 New York Academy of Sciences.

KW - Chloride

KW - Kidney

KW - Relaxin

KW - RXFP1 receptor

KW - Sodium

U2 - 10.1111/j.1749-6632.2008.03797.x

DO - 10.1111/j.1749-6632.2008.03797.x

M3 - Article

SN - 0077-8923

VL - 1160

SP - 313

EP - 316

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat

Abstract

Keywords

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