Reliability and prognostic value of radiomic features are highly dependent on choice of feature extraction platform

Isabella Fornacon-Wood, Hitesh Mistry, Christoph J. Ackermann, Fiona Blackhall, Andrew Mcpartlin, Corinne Faivre-Finn, Gareth Price, James O'Connor

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Abstract

Objective: To investigate the effects of Image Biomarker Standardisation Initiative (IBSI) compliance, harmonisation of calculation settings and platform version on the statistical reliability of radiomic features and their corresponding ability to predict clinical outcome.

Methods: The statistical reliability of radiomic features was assessed retrospectively in three clinical datasets(patient numbers: 108 head and neck cancer, 37 small cell lung cancer, 47 non-small cell lung cancer).Features were calculated using four platforms (PyRadiomics, LIFEx, CERR and IBEX).PyRadiomics, LIFEx and CERR are IBSI-compliant, whereas IBEX is not. The effect of IBSI compliance, user defined calculation settings and platform version were assessed by calculating intraclass correlation coefficients and confidence intervals. The influence of platform choice on the relationship between radiomic biomarkers and survival was evaluated using univariable coxregression in the largest dataset.

Results: The reliability of radiomic features calculated by the different software platforms was only excellent(ICC > 0.9) for 4/17 radiomic features when comparing all four platforms. Reliability improved toICC > 0.9 for 15/17 radiomic features when analysis was restricted to the three IBSI-compliant platforms. Failure to harmonise calculation settings resulted in poor reliability, even across the IBSI compliant platforms. Software platform version also had a marked effect on feature reliability inCERR and LIFEx. Features identified as having significant relationship to survival varied between platforms, as did the direction of hazard ratios.

Conclusion: IBSI compliance, user defined calculation settings and choice of platform version all influence the statistical reliability and corresponding performance of prognostic models in radiomics.
Original languageEnglish
Pages (from-to)6241–6250
Number of pages10
JournalEuropean Radiology
Volume30
Issue number11
Early online date1 Jun 2020
DOIs
Publication statusPublished - Nov 2020

Keywords

  • reliability of results
  • biomarkers
  • prognosis
  • tomography
  • X-ray computed

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