TY - JOUR
T1 - Remission and rheumatoid arthritis data on patients receiving usual care in twenty-four countries
AU - Verstappen, Suzanne
AU - Sokka, Tuulikki
AU - Hetland, Merete Lund
AU - Mäkinen, Heidi
AU - Kautiainen, Hannu
AU - Hørslev-Petersen, Kim
AU - Luukkainen, Reijo K.
AU - Combe, Bernard
AU - Badsha, Humeira
AU - Drosos, Alexandros A.
AU - Devlin, Joe
AU - Ferraccioli, Gianfranco
AU - Morelli, Alessia
AU - Hoekstra, Monique
AU - Majdan, Maria
AU - Sadkiewicz, Stefan
AU - Belmonte, Miguel
AU - Holmqvist, Ann Carin
AU - Choy, Ernest
AU - Burmester, Gerd R.
AU - Tunc, Recep
AU - Dimić, Aleksander
AU - Nedović, Jovan
AU - Stanković, Aleksandra
AU - Bergman, Martin
AU - Toloza, Sergio
AU - Pincus, Theodore
PY - 2008/9
Y1 - 2008/9
N2 - Objective. To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). Methods. The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). Results. The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was ≥15% in 10 countries, 5-14% in 7 countries, and
AB - Objective. To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). Methods. The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). Results. The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was ≥15% in 10 countries, 5-14% in 7 countries, and
U2 - 10.1002/art.23794
DO - 10.1002/art.23794
M3 - Article
C2 - 18759292
SN - 2151-464X
VL - 58
SP - 2642
EP - 2651
JO - Arthritis Care & Research
JF - Arthritis Care & Research
IS - 9
ER -