Remission and rheumatoid arthritis data on patients receiving usual care in twenty-four countries

Suzanne Verstappen, Tuulikki Sokka, Merete Lund Hetland, Heidi Mäkinen, Hannu Kautiainen, Kim Hørslev-Petersen, Reijo K. Luukkainen, Bernard Combe, Humeira Badsha, Alexandros A. Drosos, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann Carin Holmqvist, Ernest Choy, Gerd R. BurmesterRecep Tunc, Aleksander Dimić, Jovan Nedović, Aleksandra Stanković, Martin Bergman, Sergio Toloza, Theodore Pincus

    Research output: Contribution to journalArticlepeer-review


    Objective. To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). Methods. The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). Results. The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was ≥15% in 10 countries, 5-14% in 7 countries, and
    Original languageEnglish
    Pages (from-to)2642-2651
    Number of pages9
    JournalArthritis Care & Research
    Issue number9
    Publication statusPublished - Sept 2008


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