Remodelling of human atrial K + currents but not ion channel expression by chronic β-blockade

Gillian E. Marshall, Julie A. Russell, James O. Tellez, Pardeep S. Jhund, Susan Currie, John Dempster, Mark R. Boyett, Kathleen A. Kane, Andrew C. Rankin, Antony J. Workman

    Research output: Contribution to journalArticlepeer-review


    Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially antiarrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K +currents. The aim of this study was to investigate the effects of chronic β-blockade on transient outward, sustained and inward rectifier K + currents (I TO, I KSUS and I K1) in human atrial myocytes and on the expression of underlying ion channel subunits. Ion currents were recorded from human right atrial isolated myocytes using the whole-cell-patch clamp technique. Tissue mRNA and protein levels were measured using real time RT-PCR and Western blotting. Chronic β-blockade was associated with a 41% reduction in ITO density: 9.3±0.8 (30 myocytes, 15 patients) vs 15.7±1.1 pA/pF (32, 14), p
    Original languageEnglish
    Pages (from-to)537-548
    Number of pages11
    JournalPflügers Archiv European Journal of Physiology
    Issue number4
    Publication statusPublished - Apr 2012


    • β adrenoceptor
    • Action potential
    • Atrial myocyte
    • Human
    • Ion channel
    • Ion current


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