Abstract
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially antiarrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K +currents. The aim of this study was to investigate the effects of chronic β-blockade on transient outward, sustained and inward rectifier K + currents (I TO, I KSUS and I K1) in human atrial myocytes and on the expression of underlying ion channel subunits. Ion currents were recorded from human right atrial isolated myocytes using the whole-cell-patch clamp technique. Tissue mRNA and protein levels were measured using real time RT-PCR and Western blotting. Chronic β-blockade was associated with a 41% reduction in ITO density: 9.3±0.8 (30 myocytes, 15 patients) vs 15.7±1.1 pA/pF (32, 14), p
Original language | English |
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Pages (from-to) | 537-548 |
Number of pages | 11 |
Journal | Pflügers Archiv European Journal of Physiology |
Volume | 463 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2012 |
Keywords
- β adrenoceptor
- Action potential
- Atrial myocyte
- Human
- Ion channel
- Ion current